IndraLab

Statements


RPS6KB1 phosphorylates RPS6 on S240. 10 / 10
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"Similarly, p70 S6 kinase-mediated phosphorylation of ribosomal S6 at S235 and S240 was comparable between WT and Dapk −/− T cells ( xref )."
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"Its phosphorylation serves as a robust readout of mTORC1 activity, since rpS6 is phosphorylated at Serine 240 and 244 specifically by p70S6K, which is itself activated by direct phosphorylation of Thr389 by mTORC1 [24–26]."
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"S6 is phosphorylated by both S6K1 and the closely related S6K2 on Ser 240 / Ser 244 as well as Ser 235 / Ser 236."
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"These results are consistent with the conclusion that phosphorylation of S6 (S240) by S6K1 is an essential prerequisite for subsequent phosphorylation of S6 (S235) by RSK."
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"Its phosphorylation serves as a robust readout of mTORC1 activity, since rpS6 is phosphorylated at Serine 240 and 244 specifically by p70S6K, which is itself activated by direct phosphorylation of Thr 389 by mTORC1 [24] [25] [26] ."
biopax:phosphositeplus
No evidence text available
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"Similarly, p70 S6 kinase mediated phosphorylation of ribosomal S6 at S235 and S240 was comparable between WT and Dapk -/- T cells (XREF_SUPPLEMENTARY)."
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"After stimulation, S6K1 phosphorylates S6 on five serine residues (S235, S236, S240, S244, and S247) within the C-terminus [XREF_BIBR]."
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"The p70 ribosomal S6 kinases, directly regulated by mTOR, phosphorylate rpS6 on Ser 240 and Ser 244."
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"The ribosomal protein S6 is a component of the 40S ribosomal subunit and is phosphorylated at Ser 240/244 by p70S6 kinase (S6K1), a direct target of mTORC1."