IndraLab

"Its phosphorylation serves as a robust readout of mTORC1 activity, since rpS6 is phosphorylated at Serine 240 and 244 specifically by p70S6K, which is itself activated by direct phosphorylation of Thr389 by mTORC1 [24–26]."

"S6 is phosphorylated by both S6K1 and the closely related S6K2 on Ser 240 / Ser 244 as well as Ser 235 / Ser 236."

"Similarly, p70 S6 kinase mediated phosphorylation of ribosomal S6 at S235 and S240 was comparable between WT and Dapk -/- T cells (XREF_SUPPLEMENTARY)."

"Similarly, p70 S6 kinase-mediated phosphorylation of ribosomal S6 at S235 and S240 was comparable between WT and Dapk −/− T cells ( xref )."

"These results are consistent with the conclusion that phosphorylation of S6 (S240) by S6K1 is an essential prerequisite for subsequent phosphorylation of S6 (S235) by RSK."

"A recent bioinformatics study performed KEGG analysis and gene set enrichment analysis (GSEA) via Gene Expression Profiling Interactive Analysis (GEPIA) based on The Cancer Genome Atlas (TCGA) datasets and demonstrated that ACTL6A significantly affects ribosomal pathways. xref Since S6 kinase (S6K1) is a key member of the pathway, that participates in translational control, and the S6 kinase (S6K1)-S6 signaling pathway is critical for regulating proliferation and survival in response to growth factors, we focused on S6K1 as a downstream target of ACTL6A. xref S6K1 always phosphorylates S6 protein at Ser235, Ser236, Ser240, Ser244, and Ser247. xref Aberrant upregulation of S6 phosphorylation and increased S6K activity are frequently present in various tumors including ESCC. xref Although phosphorylated-ribosomal protein S6 (p-S6) is considered to be a potential target in ESCC in vitro and S6 phosphorylation has prognostic significance in ESCC, the relationship between S6 and ACTL6A remains unclear. xref "

"Its phosphorylation serves as a robust readout of mTORC1 activity, since rpS6 is phosphorylated at Serine 240 and 244 specifically by p70S6K, which is itself activated by direct phosphorylation of Thr 389 by mTORC1 [24] [25] [26] ."

No evidence text available

"After stimulation, S6K1 phosphorylates S6 on five serine residues (S235, S236, S240, S244, and S247) within the C-terminus [XREF_BIBR]."

"The p70 ribosomal S6 kinases, directly regulated by mTOR, phosphorylate rpS6 on Ser 240 and Ser 244."

"The ribosomal protein S6 is a component of the 40S ribosomal subunit and is phosphorylated at Ser 240/244 by p70S6 kinase (S6K1), a direct target of mTORC1."