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BMP inhibits COPS5. 3 / 3
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"Taken together, these results indicate that the inhibition of p53 and BMP signaling pathways can partially rescue the major defects in Jab1 cKO chondrocytes."
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"Indeed, we showed that the inhibition of both the BMP and p53 pathways could partially rescue the Jab1 cKO phenotype ex vivo and in whole tibia organ cultures, confirming that both the BMP and p53 pathways are indeed major downstream targets repressed by Jab1 in chondrocytes (Fig. 8)."
33393086
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"Interestingly, in micromass culture experiments, BMP response was decreased in the mutants, thus highlighting the differential role of Jab1 at different stages of BMP mediated growth plate development."
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