IndraLab

Statements

EGF binds EGFR and MUC1. 5 / 5
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"In pancreatic cancer, silencing of galectin-3 has shown to enhance the cell surface interaction between MUC1 and EGFR in the absence of EGF stimulation and reduced the rate of endocytosis of MUC1-EGFR complex which leads to the noticeable cell surface localization of MUC1."
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"EGF-stimulated binding of MUC1 and EGFR was attenuated by lactose and not sucrose, indicating that galectin-3 may facilitate this interaction ( Figure 7 A)."
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"Moreover, downregulation of galectin-3 by ectopic miR-322 attenuated the EGF-induced interaction between MUC1 and EGFR ( Figure 7 D)."
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"The significance of the MUC1-C-galectin-3 interaction is supported by the demonstration that galectin-3 forms a bridge between MUC1 and the epidermal growth factor receptor (EGFR) and that galectin-3 is essential for EGF-mediated interactions between MUC1 and EGFR."
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"The results demonstrate that silencing galectin-3 blocks the EGF-induced association of MUC1 and EGFR ( Figure 7 B)."
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