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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MEK binds BRAF, KRAS, and NRAS. 1 / 1

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"The identification of i) APC and KEAP1 mutations, as alternative causes of activation of β–catenin and NRF2 respectively; ii) the association of BRAF , KRAS and NRAS mutations with MEK-inhibition sensitivity, and iii) our successful validation of the role of NOX5 in NRF2 activation, and the chr8q23–4 amplicon in predicting KRAS dependency, all provide a direct confirmation of REVEALER’s utility and effectiveness."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...