IndraLab

Statements

USP30 activates autophagy of mitochondrion. 3 / 3
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"Nevertheless, deletion of USP30 from cells with endogenous Parkin only results in a modest effect on mitophagic flux, and Parkin can rapidly overcome USP30’s activity to allow maximal activation of the Parkin dependent mitophagy ."
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"More specifically, USP30 has been reported to mediate Parkin and PINK1-dependent mitophagy following the acute depolarization of the mitochondria [9] via the deubiquitylating Parkin substrates in the mitochondria [10]."
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"A small molecule targeting USP30 acts to enhance cardiac mitophagy in vivo [132], although it is unclear why mitophagy was not induced in other tissues."
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