IndraLab

Statements

BAP1 increases the amount of ITPR3. 3 / 3
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"Remarkably, depletion of BAP1 or IP3R3 promoted crocidolite asbestos and TNF-alpha-induced transformation of primary mesothelial cells, and re-expression of IP3R3 in BAP1 depleted cells partially reverted the phenotype."
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"Transduction of BAP1 +/- fibroblasts with adenoviruses encoding BAP1, but not the catalytic inactive mutant BAP1 (C91S) XREF_BIBR, XREF_BIBR, rescued IP3R3 protein levels (XREF_FIG), mitochondrial Ca 2+ uptake (XREF_FIG, XREF_FIG, XREF_SUPPLEMENTARY) and resulted in enhanced apoptosis (XREF_FIG)."
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"Silencing of BAP1 in BAP1 WT fibroblasts consistently caused a reduction of IP3R3 protein levels (XREF_FIG), with concomitant reduction of mitochondrial Ca 2+ responses (XREF_FIG, and XREF_SUPPLEMENTARY), and protection from apoptosis (XREF_FIG)."
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