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Lipopolysaccharide activates TNFAIP3. 16 / 16
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"In fact, this process would be similar to the tolerance induced by LPS pre-stimulation that upregulates TNFAIP3 as a negative feedback factor driving the inhibition of NF-kB signaling pathway."
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"Indeed, in our study LPS rapidly upregulated TNFAIP3 and IRAK-M, but it significantly reduced Sp1 levels."
35198762
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"Lipopolysaccharide (LPS) stimulation increases NF-κB dependent expression of tumor necrosis factor alpha-induced protein 3 (TNFAIP3/A20) or miR-146a, which both negatively regulate NF-κB signaling [11, 14]."
39550582
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"To test whether Tnfaip3 -/- cells might release such ligands, we stimulated LPS primed control BMDMs with supernatants from LPS stimulated Tnfaip3 -/- cells and assayed for additional IL-1beta production by control cells."
25607459
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"We thus utilized anti-G-G antibody assisted mass spectrometry to find potential ubiquitinated IL-1beta peptides from LPS stimulated Tnfaip3 -/- BMDMs."
25607459
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"While LPS upregulated both IL-12p40 and TNFAIP3 and A20 production, adding DEHP to cultures dramatically reduced IL-12p40 and TNFAIP3 and A20 levels."
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"These results showed that TNFAIP3 induced by LPS is insufficient for persistently inflammatory stimulation, and TNFAIP3 may be important for the metabolism in nucleus pulposus cells, providing a new research idea for the treatment and prevention of degenerative diseases."
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"The LPS induced immune markers, specifically TLR4, TNF alpha induced protein 3 (TNFAIP3) and interleukin-1 receptor associated kinase like 2 (IRAK2), were identified among the strongest variables of the PC1, along with the increase in expression of genes related to mitochondrial metabolism (e.g. NADH dehydrogenase (ubiquinone) 1 beta sub-complex 5; NDUFB5)."
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"Lipopolysaccharide (LPS) stimulation increases NF-κB dependent expression of tumor necrosis factor alpha-induced protein 3 (TNFAIP3/A20) or miR-146a, which both negatively regulate NF-κB signaling [11, 14]."
39550582
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"As shown in 420 Figure 6C , both LPS , and the 1 +2 mixture co-added with LPS , induced significant 421 expression of A20 gene within 60 minutes after addition to the cells ."
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"The addition of BzATP/LPS to microglia caused a small but significant increase in TNFaIP3 protein in the cytoplasm (p < 0.05)."
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"We found that LPS induced a significant increase in TNFAIP3 but that Pam3CsK4 induced only a slight increase."
35198762
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"In our results, TNFAIP3 (A20) and NFKBIA were up-regulated by LPS, but down-regulated by BV treatment."
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"miR-98-5p inhibition and 3β-hydroxycholest-5- en -7-one treatment significantly increased LPS-induced TNFAIP3 downregulation, which blocked NF-κB activation and proinflammatory cytokine production.In [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32771556
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"Secondly, in parallel to what was observed in cambinol treated cells, we also observed a significant upregulation of such LPS induced genes as ADORA2A, RUNX3, TNFAIP3 and SLC1A2 in MACs treated with DAC following LPS stimulation."
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"In contrast, LPS-induced upregulation of A20 (also called TNFAIP3), which relies on de novo gene transcription, was prevented by actinomycin D ( Figure 1 I)."
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