IndraLab

Statements

USP7 activates cell death. 10 / 11
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"Targeting USP7 in GBM is therefore expected to cause cell death for therapeutic purposes.GBM cell death can be achieved by promoting apoptosis [16]."
34556124
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"Like USP7 inhibition, forcing PTEN to the nucleus is sufficient to induce apoptosis in CLL cells, thus strongly suggesting that apoptotic cell death caused by USP7 inhibition is mediated by reactivation of the nuclear pro apoptotic function of PTEN [XREF_BIBR], and that PTEN exerts tumor suppressive functions mostly from the nucleus in CLL."
28473667
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"Immunohistochemistry and TUNEL staining revealed that LINC01088‐SH reduced the expression of proteins such as Ki‐67, HLTF, USP7, and SLC7A11, thereby increasing GBM cell death."
40000422
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"The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status."
29049989
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"USP7 silencing in HL-60 cells significantly reduced cell proliferation by increasing apoptotic cell death and the proportion of cells in the G1 phase."
32447346
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"Cartel et al. (2021) demonstrated that USP7 inhibition significantly reduces cell proliferation in vitro and in vivo, blocks the progression of DNA replication, and increases cell death in Acute Myeloid Leukemia (AML) [38]."
37373211
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"In this report, we found that PdPT is an inhibitor of multiple DUBs including USP7, USP10, USP14, USP15, USP25 and UCHL5, which contributes to the accumulation of ubiquitinated proteins and subsequent cell death in NSCLC cell lines.Regulated cell death requires activation of various regulators and effectors (23)."
32596160
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"As illustrated in Figure 5C, USP7 knockdown effectively reduced cell death rates in LPS-challenged cells as well as in those treated with LPS and TGF-β1 (Figure 5C)."
38966570
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"Together, our data therefore indicate that I3MO downregulates the level of USP7 and promotes NEK2 degradation, resulting in the suppression of downstream targets and NF-κB signaling, and inducing cell death in bortezomib resistant MM cells."
35344764
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"USP7 is an oncogene in pancreatic cancer, and USP7 inhibition blocks PDAC development and promotes cell death in vitro and in vivo [48]."
37605223