IndraLab

Statements

USP7 activates cell death. 7 / 8
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"Interestingly, the addition of SCH900776 in P22077 and cytarabine-treated cells did not increase cell death, which suggests that P22077induced cell death is mediated by the USP7/CHK1 axis."
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"Targeting USP7 in GBM is therefore expected to cause cell death for therapeutic purposes.GBM cell death can be achieved by promoting apoptosis [16]."
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"Like USP7 inhibition, forcing PTEN to the nucleus is sufficient to induce apoptosis in CLL cells, thus strongly suggesting that apoptotic cell death caused by USP7 inhibition is mediated by reactivation of the nuclear pro apoptotic function of PTEN [XREF_BIBR], and that PTEN exerts tumor suppressive functions mostly from the nucleus in CLL."
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"The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status."
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"In this paper, we demonstrate that inhibition of deubiquitinylase USP7 significantly reduces cell proliferation in vitro and in vivo, blocks DNA replication progression and increases cell death in AML."
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"USP7 silencing in HL-60 cells significantly reduced cell proliferation by increasing apoptotic cell death and the proportion of cells in the G1 phase."
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"In this report, we found that PdPT is an inhibitor of multiple DUBs including USP7, USP10, USP14, USP15, USP25 and UCHL5, which contributes to the accumulation of ubiquitinated proteins and subsequent cell death in NSCLC cell lines.Regulated cell death requires activation of various regulators and effectors (23)."
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