IndraLab

Statements

CASP8 binds CYLD. 2 / 2
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sparser
"Interaction between transfected CYLD and CASPASE 8 by co-immunoprecipitation was observed only when the activity of CASPASE 8 was blocked by the pan-caspase inhibitor zVAD-fmk, or by mutation of the CASPASE 8 active site, suggesting that CYLD is a substrate for proteolytic cleavage by CASPASE 8 ( xref )."
22037414
sparser
"Thus, the CASPASE-8:CYLD interaction is an early switch that determines survival versus necroptotic death in the TNFR1 pathway."
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