IndraLab

Statements

STAT1 activates USP18. 3 / 3
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"This study showed that type I IFNs (but not type II IFNs) were required for CD95 induced stemness and did so through the phosphorylation and activation of STAT1 and upregulation of the STAT1 targets PLSCR1, USP18, and HERC8."
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reach
"The second mechanism is the recently described inhibition of STAT1 phosphorylation by UBP43 (the product of ISG43) through its inhibition of JAK1 interaction with the IFNAR2 subunit of the type I IFN receptor XREF_BIBR."
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eidos
"STAT1 , USP18 and IRF1 modulate CXCL10 levels in EC following IFN-alpha stimulation To validate the transcriptional regulations inferred in our multiple-output FFL regulatory subnetwork ( Fig. 2 ) , we measured CXCL10 protein levels in tissue culture media conditioned by STAT1 - , USP18 - , IFIH1 - and IRF1-silenced HUVECs , compared to HUVECs transfected with a scrambled siRNA ( siCTRL ) ."
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