IndraLab

Statements

COPS6 inhibits TP53. 5 / 5
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"Moreover, CSN6 promotes p53 degradation through a mechanism that stabilizes MDM2 protein by limiting its auto-ubiquitylation."
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"Similarly, it was found that over-expression of CSN6 can promote p53 degradation through inhibiting autoubiquitylation of MDM2, and mice that were heterozygous for CSN6 were more susceptible to DNA damage [XREF_BIBR]."
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"Moreover, CSN6 could n't induce p53 degradation in Mdm2-null mouse embryonic fibroblasts, suggesting that CSN6 mediated degradation of p53 is MDM2 dependent."
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"These results suggest that loss of CSN6 enhances p53 mediated tumor suppression in vivo and that CSN6 plays an important role in regulating DNA damage associated apoptosis and tumorigenesis through control of the MDM2-p53 signaling pathway."
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"Through combinatorial effects on the MDM2-p53 signaling axis and now SKP2 mediated p57 Kip2 degradation, it is hypothesized that CSN6 overexpression can effectively promote cell proliferation by simultaneously relieving cell cycle restraints, apoptosis, senescence, and presumably p53 functions in DNA damage repair and cell metabolism, among other important tumor suppressive mechanisms."
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