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PSMD14 activates ESR. 4 / 4
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"Further examination of the effect of wild type and enzyme deficient forms of PSMD14 (H113Q, C120S, H113Q/C120S) on modulating ERα stability showed that the wild type form of PSMD14 can enhance ERα stability, while the catalytic deficient forms of PSMD14 are unable to do so (Fig. 5N, O)."
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"The estrogen response element luciferase assay demonstrated that PSMD14 depletion inhibited ERα signaling activity in both vehicle and estradiol-treated conditions in MCF-7 and T47D cells (Fig. 4G, H)."
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"Additionally, the estrogen response element luciferase assay revealed that PSMD14 overexpression enhanced ERα signaling activity in MCF-7 cells (Fig. 4M)."
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"Additionally, the protein stability assay using the protein synthesis inhibitor cycloheximide demonstrated that PSMD14 depletion in MCF-7 and T47D cells decreases ERα protein half-life (Fig. 5J–M)."
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