IndraLab

Statements

IKK_complex binds CYLD. 6 / 7
| 3 3
sparser
"It will be interesting to examine whether the binding of CYLD to the IKK regulators is dependent on NEMO."
19373246
reach
"We show that CYLD binds to the NEMO (also known as IKKgamma) component of the IkappaB kinase (IKK) complex, and appears to regulate its activity through de-ubiquitination of TRAF2, as TRAF2 ubiquitination can be modulated by CYLD."
12917690
sparser
"Biochemical and genetic evidence suggests that IKK is a kinase that mediates CYLD phosphorylation. xref As CYLD physically interacts with the IKK regulatory subunit, NEMO, it is likely that CYLD is recruited to the IKK holoenzyme by NEMO."
19373246
reach
"It will be interesting to examine whether the binding of CYLD to the IKK regulators is dependent on NEMO."
19373246
sparser
"Thus, future work should examine how the interaction of CYLD and IKK fits into overall landscape of IKK-mediated neuronal function and pathology."
24928390
reach
"Thus, future work should examine how the interaction of CYLD and IKK fits into overall landscape of IKK mediated neuronal function and pathology."
24928390