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EIF3F activates apoptotic process. 44 / 56
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"Interaction of Mss4 with eIF3F prevents the eIF3F mediated apoptosis."
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"EIF3f overexpression affects cell viability in alveolar A549 cancer cells and induces apoptosis."
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"The data also suggest that eIF3f inhibits cancer cell growth and induces apoptosis by blocking the function of sCLU, thereby suppressing the inactivation of p53 and Bax as well as the Akt and ERK pathways."
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"In human A549 cells, eIF3f exhibits a fluctuating expression pattern in cycling cells, with maximum expression peaks in G1/S and in G2/M; transient expression analysis showed that eIF3f deregulation compromises cell viability and induces apoptosis [XREF_BIBR]."
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"Another, the expression of eIF3f is downregulated in many human tumors, the overexpression of eIF3f inhibits cell proliferation, and induces apoptosis in tumor cells ( Doldan et al., 2008; Shi et al.,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Downregulation of eIF3f expression by antisense-eIF3f markedly increased apoptosis in A549 cells."
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"These results clearly show that eIF3f is essential for the viability of A549 lung adenocarcinoma cells and that silencing of this gene promotes apoptosis; in agreement with this result, we found that downregulation of eIF3f expression in plant cells also induced apoptosis (unpublished data)."
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"We next defined the relationship among p53, p21, and Bax during eIF3f induced apoptosis."
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"Our data show that deregulation of eIF3f in A549 cells induce apoptosis by means of a caspase-9 independent pathway (data not shown)."
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"Overexpression of eIF3f induces apoptosis in pancreatic cancer cells."
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"Of note, only overexpression of wt Mss4 protein but not the F75A mutant that can not bind to eIF3f was able to inhibit the eIF3f mediated apoptosis."
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"EIF3f induces apoptosis by inhibiting protein synthesis and proliferation in pancreatic cancer and melanoma cells, whereas eIF3f may act as a negative regulator of translational effects, and its low expression protects melanoma cells from apoptosis [67]."
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"Overexpressing eIF3f inhibits cell proliferation and induces apoptosis."
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"Overexpression of eIF3f inhibits translation and induces apoptosis in melanoma cells."
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"Conversely, eIF3f expression is a tumor suppressor in several cancers, including melanoma and pancreatic cancer, and overexpress eIF3f inhibits cell proliferation and induces apoptosis[ 29 ]."
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"EIF3F overexpression induces apoptosis in pancreatic and melanoma cancer cells and disrupts the proliferation of tumor cells (32,34,35)."
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"Overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR Advances in the understanding of the molecular mechanism behind cellular carcinogenesis have shown that ectopic expression of eIF3f by transient gene transfection inhibits translation, cellular growth and proliferation and induces apoptosis."
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"To investigate whether the phosphor-mimic eIF3f SETE mutant promotes apoptosis, we transfected eIF3f SETE alone or with CDK11 p46 or CDK11 p46M into A375 cells."
19245811
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"It has been shown that in melanoma and pancreatic cancer cells eIF3f can induce apoptosis in caspase 3/7 and in a Bcl-2, Bax, or Bcl-XL-independent manner."
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"We also showed that restored eIF3f expression in tumor cells causes ribosomal RNA (rRNA) degradation, inhibits translation and cell proliferation, and induces apoptosis XREF_BIBR."
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"Restoration of eIF3f expression in BxPC3 and MiaPaCa-2 pancreatic cancer cells induced apoptosis (XREF_SUPPLEMENTARY)."
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"EIF3f overexpression in cancer inducing apoptosis."
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"We also previously showed that ectopic expression of eIF3f inhibited cell growth and induced apoptosis XREF_BIBR."
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"XREF_BIBR Overexpression of eIF3f inhibits cell proliferation, induces apoptosis, and inhibits translation and protein expression."
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"The overexpression of eIF3f retarded cancer cell growth and induced apoptosis 51."
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"Western blot analyses have demonstrated that eIF3f induces apoptosis in caspase 3/7 and in a Bcl-2-, Bax- or Bcl-XL-independent manner [XREF_BIBR]."
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"18, 28 In this study, we demonstrated that overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, suggesting that down-regulation of eIF3f is involved in tumorigenesis for many types of cancer."
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"It is demonstrated that the enforced expression of eIF3f inhibits translation, cell growth, cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, while knockdown of eIF3f i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Increased eIF3f expression contributes to apoptosis via hnRNP K sequestration and increased rRNA degradation."
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"The overexpression of eIF3f retarded cancer cell growth significantly and induced apoptosis."
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"Overexpression of eIF3f induces rRNA degradation and apoptosis [XREF_BIBR]."
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"However, the molecular mechanism by which the increased expression of eIF3f induces apoptosis is poorly understood."
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"In the current study, we found that eIF3f induced apoptosis and inhibited tumor growth in vitro and in vivo."
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"The overexpression of eIF3f inhibits cancer cell growth and induces apoptosis."
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"These results suggest that the overexpression of eIF3f induces apoptosis in cancer cells, and that the reduced number of eIF3f transfected cells was due to an increased level of spontaneous apoptosis."
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"Deregulation of eIF3f expression negatively affects cell viability and induces apoptosis."
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"Increased levels of eIF3f expression are found to compromise proliferation and promote apoptosis in cancer cells [XREF_BIBR], of which this pro apoptotic property of eIF3f is presumably dependent on its interplay with CDK11 and the mammalian target of rapamycin (mTOR) [XREF_BIBR, XREF_BIBR]."
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"Therefore, eIF3f inhibits cancer cell growth and induces apoptosis by inhibiting sCLU function."
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"EIF3f is down-regulated in many human tumours, and over-expression of eIF3f inhibits cell proliferation and induces apoptosis in tumour cells (Shi etal., 2006; 2008a, 2008b)."
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"Previous studies have demonstrated that overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, suggesting that downregulation of eIF3f is involved in tumorigenesis for many types of cancer [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"EIF3f SETE mutant alone did induce more apoptosis than wild type eIF3f (XREF_FIG)."
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"Moreover, increased eIF3f inhibits translation and cell growth and induces apoptosis in melanoma and pancreatic cancer cells [XREF_BIBR]."
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"In addition, eIF3f reduces cell growth and increases apoptosis significantly in HeLa and BxPc-3 cells."
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