The INDRA Database

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"Interaction of Mss4 with eIF3F prevents the eIF3F mediated apoptosis."

22495352

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"To investigate whether the phosphor-mimic eIF3f SETE mutant promotes apoptosis, we transfected eIF3f SETE alone or with CDK11 p46 or CDK11 p46M into A375 cells."

19245811

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"Deregulation of eIF3f expression negatively affects cell viability and induces apoptosis."

20462454

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"Increased eIF3f expression contributes to apoptosis via hnRNP K sequestration and increased rRNA degradation."

23354061

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"However, the molecular mechanism by which the increased expression of eIF3f induces apoptosis is poorly understood."

26988917

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"It has been shown that in melanoma and pancreatic cancer cells eIF3f can induce apoptosis in caspase 3/7 and in a Bcl-2, Bax, or Bcl-XL-independent manner."

26052528

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"EIF3f SETE mutant alone did induce more apoptosis than wild type eIF3f (XREF_FIG)."

19245811

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"In addition, eIF3f reduces cell growth and increases apoptosis significantly in HeLa and BxPc-3 cells."

26988917

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"Restoration of eIF3f expression in BxPC3 and MiaPaCa-2 pancreatic cancer cells induced apoptosis (XREF_SUPPLEMENTARY)."

22457825

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"Moreover, increased eIF3f inhibits translation and cell growth and induces apoptosis in melanoma and pancreatic cancer cells [XREF_BIBR]."

26988917

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"Our data show that deregulation of eIF3f in A549 cells induce apoptosis by means of a caspase-9 independent pathway (data not shown)."

20462454

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"Previous studies have demonstrated that overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, suggesting that downregulation of eIF3f is involved in tumorigenesis for many types of cancer [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

24678890

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"We also previously showed that ectopic expression of eIF3f inhibited cell growth and induced apoptosis XREF_BIBR."

22457825

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"In the current study, we found that eIF3f induced apoptosis and inhibited tumor growth in vitro and in vivo."

26988917

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"In human A549 cells, eIF3f exhibits a fluctuating expression pattern in cycling cells, with maximum expression peaks in G1/S and in G2/M; transient expression analysis showed that eIF3f deregulation compromises cell viability and induces apoptosis [XREF_BIBR]."

26497985

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"Of note, only overexpression of wt Mss4 protein but not the F75A mutant that can not bind to eIF3f was able to inhibit the eIF3f mediated apoptosis."

22495352

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"EIF3f is down-regulated in many human tumours, and over-expression of eIF3f inhibits cell proliferation and induces apoptosis in tumour cells (Shi etal., 2006; 2008a, 2008b)."

20444226

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"EIF3f overexpression in cancer inducing apoptosis."

23354061

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"These results clearly show that eIF3f is essential for the viability of A549 lung adenocarcinoma cells and that silencing of this gene promotes apoptosis; in agreement with this result, we found that downregulation of eIF3f expression in plant cells also induced apoptosis (unpublished data)."

20462454

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"Overexpression of eIF3f inhibits translation and induces apoptosis in melanoma cells."

18381585

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"Overexpression of eIF3f induces apoptosis in pancreatic cancer cells."

17918192

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"Western blot analyses have demonstrated that eIF3f induces apoptosis in caspase 3/7 and in a Bcl-2-, Bax- or Bcl-XL-independent manner [XREF_BIBR]."

23354061

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"Increased levels of eIF3f expression are found to compromise proliferation and promote apoptosis in cancer cells [XREF_BIBR], of which this pro apoptotic property of eIF3f is presumably dependent on its interplay with CDK11 and the mammalian target of rapamycin (mTOR) [XREF_BIBR, XREF_BIBR]."

23725059

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"Therefore, eIF3f inhibits cancer cell growth and induces apoptosis by inhibiting sCLU function."

26988917

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"The data also suggest that eIF3f inhibits cancer cell growth and induces apoptosis by blocking the function of sCLU, thereby suppressing the inactivation of p53 and Bax as well as the Akt and ERK pathways."

26988917

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"The overexpression of eIF3f retarded cancer cell growth and induced apoptosis 51."

29167521

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"We next defined the relationship among p53, p21, and Bax during eIF3f induced apoptosis."

26988917

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"We also showed that restored eIF3f expression in tumor cells causes ribosomal RNA (rRNA) degradation, inhibits translation and cell proliferation, and induces apoptosis XREF_BIBR."

22457825

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"EIF3f is down-regulated in many human tumours, and over-expression of eIF3f inhibits cell proliferation and induces apoptosis in tumour cells (Shi et al., 2006; Doldan et al., 2008a,b) ."

20444226

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"These results suggest that the overexpression of eIF3f induces apoptosis in cancer cells, and that the reduced number of eIF3f transfected cells was due to an increased level of spontaneous apoptosis."

26988917

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"The overexpression of eIF3f retarded cancer cell growth significantly and induced apoptosis."

26988917

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"XREF_BIBR, XREF_BIBR, XREF_BIBR Advances in the understanding of the molecular mechanism behind cellular carcinogenesis have shown that ectopic expression of eIF3f by transient gene transfection inhibits translation, cellular growth and proliferation and induces apoptosis."

26052528

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"Previous studies have demonstrated that overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, suggesting that downregulation of eIF3f is involved in tumorigenesis for many types of cancer [11, 16, 19] ."

24678890

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"EIF3f overexpression affects cell viability in alveolar A549 cancer cells and induces apoptosis."

20462454

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"18, 28 In this study, we demonstrated that overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, suggesting that down-regulation of eIF3f is involved in tumorigenesis for many types of cancer."

25684180

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"The overexpression of eIF3f inhibits cancer cell growth and induces apoptosis."

26988917

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"Overexpression of eIF3f induces rRNA degradation and apoptosis [XREF_BIBR]."

19245811

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"XREF_BIBR Overexpression of eIF3f inhibits cell proliferation, induces apoptosis, and inhibits translation and protein expression."