IndraLab

Statements

USP7 inhibits cell death. 11 / 11
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"In this paper, we demonstrate that inhibition of deubiquitinylase USP7 significantly reduces cell proliferation in vitro and in vivo, blocks DNA replication progression and increases cell death in AML."
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"However, senescent p53 knockout cells were resistant to apoptosis and cell death caused by USP7 inhibition with P5091 (Figure 3a, b)."
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"We subsequently examined the possibility that USP7 inhibition might trigger cell death in canine lymphoma and leukemia cells."
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"Furthermore, targeting USP7 contributed to CDDO-Me-induced ovarian cancer cell death, suggesting that USP7 is a novel drug target in ovarian cancer cells."
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"Disruption of the USP7 function induces HCC cell death and inhibits cell proliferation and migration, which might be due to BCL2 associated X (BAX) activation."
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"Having analyzed cell cycle progression, we investigated if USP7 inhibition causes any particular type of cell death."
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"USP7 knockdown effectively induced cell death in several cancer cells of lung, prostate, and cervix."
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"USP7 knockdown effectively induced cell death in several cancer cells of lung , prostate , and cervix ."
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"In particular, pharmaceutical inhibition of USP7 by the small molecule P22077 attenuated PDAC cell growth and induced cell death in vitro and in vivo."
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"Our study demonstrates that loss of HAUSP in colorectal cancer cells potentiates cell death by apoptosis after exposure to various HDAC inhibitors, thus suggesting the potential of a combination of HDAC1 and HAUSP inhibitors as an effective cancer therapy."
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"For instance, the loss of HAUSP in colorectal cancer cells potentiates apoptotic cell death by inducing proteasomal degradation of DNMT1, further compounding the potential of HAUSP inhibition as an effective anti-cancer therapy XREF_BIBR - XREF_BIBR."
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