IndraLab

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USP7 inhibits cell death. 20 / 20
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"In particular, pharmaceutical inhibition of USP7 by the small molecule P22077 attenuated PDAC cell growth and induced cell death in vitro and in vivo."
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"In this paper, we demonstrate that inhibition of deubiquitinylase USP7 significantly reduces cell proliferation in vitro and in vivo, blocks DNA replication progression and increases cell death in AML."
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"However, senescent p53 knockout cells were resistant to apoptosis and cell death caused by USP7 inhibition with P5091 (Figure 3a, b)."
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"For instance, the loss of HAUSP in colorectal cancer cells potentiates apoptotic cell death by inducing proteasomal degradation of DNMT1, further compounding the potential of HAUSP inhibition as an effective anti-cancer therapy XREF_BIBR - XREF_BIBR."
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"Elevated expression of USP7 has been observed in MM, and inhibition of USP7 can antagonize proliferation and induce cell death [84], thus representing a potential anti-tumor strategy [85]."
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"The results showed that USP7 overexpression significantly inhibited sorafenib-mediated proliferation inhibition, cell death, and apoptosis induction, which was reversed by c-Myc silencing (p<0.01) (Figure 2H–J)."
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"These hypotheses were further supported by our finding that the USP7-mediated stabilization of FBXO7 inhibited cell death under ER stress."
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"Wang et al. (2017) reported that the inhibition of USP7 could induce cell death in ovarian cancers, regardless of the P53 status."
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"To do so, we applied flow cytometry analysis, and found that USP7 inhibition increased the number of cell death."
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"Furthermore, targeting USP7 contributed to CDDO-Me-induced ovarian cancer cell death, suggesting that USP7 is a novel drug target in ovarian cancer cells."
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"As shown in Fig. 7 A and B, ERα overexpression potently blocked USP7 knockdown-induced cell death."
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"Inhibition of USP7 attenuates cell growth and induces cell death in PDAC."
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"On the other hand, the literature found that short-term inhibition of USP7 activity causes uncontrolled activation of CDK1 to promote cell death [22]."
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"We subsequently examined the possibility that USP7 inhibition might trigger cell death in canine lymphoma and leukemia cells."
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"Having analyzed cell cycle progression, we investigated if USP7 inhibition causes any particular type of cell death."
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"USP7 knockdown effectively induced cell death in several cancer cells of lung, prostate, and cervix."
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"Our study demonstrates that loss of HAUSP in colorectal cancer cells potentiates cell death by apoptosis after exposure to various HDAC inhibitors, thus suggesting the potential of a combination of HDAC1 and HAUSP inhibitors as an effective cancer therapy."
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"Disruption of the USP7 function induces HCC cell death and inhibits cell proliferation and migration, which might be due to BCL2 associated X (BAX) activation."
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"Additionally, USP7 is connected to the activation of the inflammasome (Palazón-Riquelme et al. 2018) and attenuates endoplasmic reticulum stress-induced cell death (Lee and Chung 2023)."
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"The overexpression of USP7 has been observed in prostate cancer, myeloma cells, neuroblastoma, breast cancer, and ovarian cancer, while inhibiting USP7 can restrain proliferation and induce cell death[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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