IndraLab

Statements

Hydroxychloroquine inhibits KCNH2. 30 / 30
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"Hydroxychloroquine is known to block Kv11.1 ( HERG ) and can cause drug-induced long-QT syndrome [ 5 ] ."
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"Our results showed that while chloroquine acutely blocked hERG current (I hERG) with an IC 50 of 3.0 microM, hydroxychloroquine acutely blocked I hERG 8-fold less potently, with an IC50 of 23.4 microM."
| PMC
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"Hydroxychloroquine ( HCQ ) is known to block Kv11.1 ( HERG ) and can cause drug-induced LQT ."
| PMC
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"HCQ is known to block Kv11.1 ( HERG ) and can cause drug-induced LQT ."
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"Key Results: Chloroquine and hydroxychloroquine blocked hERG with IC50 of 1.47±0.07 µM and 3.78±0.17 µM respectively, indicating proarrhythmic risk at concentrations effective against SARS-CoV-2 in vitro and proposed in COVID-19 clinical trials."
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"HCQ can block the KCNH2 encoded hERG and Kv11.1 potassium channel and thereby carries a risk of drug induced QT prolongation and cardiac arrest."
32835316
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"HCQ blocks the KCNH2-encoded hERG/ Kv11.1 potassium channel and can cause QTc prolongation and spontaneous ventricular arrhythmias and induce sudden cardiac arrest due to torsades de pointes ventricular tachycardia (7)."
| PMC
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"10 Hydroxychloroquine ( HCQ ) is known to block Kv11.1 ( HERG ) and can cause drug-induced LQT [ 34 ] ."
| PMC
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"10 Hydroxychloroquine ( HCQ ) is known to block Kv11.1 ( HERG ) and can cause drug-induced LQT [ 34 ] ."
| PMC
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"For instance, among COVID-19 treatment drugs, chloroquine and hydroxychloroquine were demonstrated to block hERG potassium channels, whereas azithromycin and remdesivir did not [143] ."
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"Treatment of Brefeldin A (BFA) and HCQ combination reduced hERG protein to a greater extent than BFA alone."
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"HCQ is not only known to mildly block the human ethera-go-go related gene (hERG) aka KCNH2 that codes for delayed rectifier potassium channel, but also the inward-rectifier potassium channel [111]."
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"Finally, hydroxychloroquine blocks the KCNH2 encoded hERG and Kv11.1 potassium channel and can potentially prolong the corrected QT interval, with potentially severe consequences, such as sudden cardiac death and cardiac arrhythmia in patients with covid-19."
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"HCQ reduced the mature hERG protein in a time and concentration-dependent manner."
37231805
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"Hydroxychloroquine is known to block Kv11.1 ( HERG ) and can cause drug-induced long QT ."
32228309
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"Hydroxychloroquine is known to block Kv11.1 (HERG) and can cause drug-induced long-QT syndrome [5]."
32333026
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"HCQ is not only known to mildly block the human ether-a-go-go related gene (hERG) aka KCNH2 that codes for delayed rectifier potassium channel, but also the inward-rectifier potassium channel [XREF_BIBR]."
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"Chloroquine and hydroxychloroquine blocked hERG with IC 50 of 1.47±0.07 μM and 3.78±0.17 μM respectively, indicating proarrhythmic risk at concentrations effective against SARS-CoV-2 in vitro."
34837219
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"Hydroxychloroquine is believed to act on the entry and post-entry stages of COVID-19 and blocks the hERG potassium channel, therefore potentially prolonging QTc [XREF_BIBR]."
33307378
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"HCQ is known to block Kv11.1 ( HERG ) and induce prolong QT , thus predisposing the patient to malignant arrhythmia such as torsade de points.70 , 71 However , studies have found that these arrhythmic toxicities are mostly encountered in chronic use with multiple concomitant QT prolonging agents , metabolic abnormalities , renal insufficiency , as well as medication overdose.72 , 73 Because the use of HCQ in COVID-19 has relatively short duration , the risk of developing significant arrhythmia is relatively low ."
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"Hydroxychloroquine is known to block Kv11.1 (HERG) and can cause drug-induced long QT."
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"XREF_FIG shows that Hydroxychloroquine and Chloroquine inhibited the hERG current with IC50 values of 9.7 and 7.77 microM, respectively, but Azithromycin had no effect."
33483756
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"Chloroquine and hydroxychloroquine blocked hERG with IC 50 of 1.47 + / -0.07 muM and 3.78 + / -0.17 muM respectively , indicating proarrhythmic risk at concentrations effective against SARS-CoV-2 in vitro ."
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"The main mechanism of HCQ induced QT prolongation is blockage of hERG K + channels [XREF_BIBR]."
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"Hydroxychloroquine attenuates hERG channel by promoting the membrane channel degradation: computational simulation and experimental evidence for QT-interval prolongation with hydroxychloroquine treatment."
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"KEY RESULTS Chloroquine and hydroxychloroquine blocked hERG with IC50 of 1.47 + / -0.07 muM and 3.78 + / -0.17 muM respectively , indicating proarrhythmic risk at concentrations effective against SARS-CoV-2 in vitro ."
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"We found that Chloroquine inhibits hERG, Nav1.5, and Cav1.2 channels, whereas Hydroxychloroquine inhibits hERG and Cav1.2 channels."
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"39, 40 Indeed, the duration of phase 2 of the action potential is prolonged through hydroxychloroquine inhibition of the hERG channels, slowing the potassium rapid inward currents (iKr), and by means of sodium current enhancement exerted by azithromycin on SC5NA."
| PMC
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"Our results showed that while chloroquine acutely blocked hERG current (I hERG) with an IC 50 of 3.0 microM, hydroxychloroquine acutely blocked I hERG 8-fold less potently, with an IC 50 of 23.4 microM."
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"Additionally, for hydroxychloroquine, a recent study pointed out that hydroxychloroquine could lead to unwanted QT interval prolongation by blocking the KCNH2 encoded hERG and Kv11.1 potassium channel, thereby increasing the risk of drug induced torsade de pointes and sudden cardiac death."
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