IndraLab

"IL-1β or LPS binding to IL-1R or TLR4, respectively, results in the rapid association of the adaptor molecule Myd88 with the receptors and subsequent recruitment of the kinases IRAK1 and IRAK4. xref Activation and phosphorylation of IRAK kinases leads to the recruitment of the E3 ubiquitin ligase TRAF6 which undergoes K63-linked autoubiquitination and serves as a scaffold to recruit TAK1 and IKK kinases through binding to TAB2/3 and NEMO, respectively. xref TAK1 is subsequently activated and triggers IKK/NF-κB and mitogen-activated protein kinase/c-Jun N-terminal kinase activation. xref "