IndraLab

Statements

RAF1 phosphorylated on S338 is active. 8 / 8
3 5 |
signor
"P21-activated protein kinases (paks) are serine/threonine protein kinases that phosphorylate raf-1 at ser-338 and ser-339."
18775988
signor
"Protein phosphatase 5 (PP5) was identified as an inactivator that associates with Raf-1 on growth factor stimulation and selectively dephosphorylates an essential activating site, Ser 338. The PP5-mediated dephosphorylation of Ser 338 inhibited Raf-1 activity and downstream signalling to MEK"
16892053
biopax:pid
No evidence text available
17569879
biopax:pid
No evidence text available
16892053
signor
"PHLPP1 and PHLPP2 dephosphorylate RAF1 to reduce its signaling, increase the invasive and migratory activities of CRC cells, and activate the epithelial-mesenchymal transition. In Apc(Min) mice, loss of PHLPP1 promotes tumor progression."
24530606
signor
"Interaction between active pak1 and raf-1 is necessary for phosphorylation and activation of raf-1."
11733498
biopax:pid
No evidence text available
16129686
signor
"The protein kinase pak3 positively regulates raf-1 activity through phosphorylation of serine 338."
9823899