IndraLab

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IRS1 decreases the amount of IRS1. 12 / 14
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"Also, upon the activation of JNK, the interaction of IRS-1 (insulin receptor substrate 1) with PP4 causes the decreased expression of IRS-1 and increased phosphorylation of IRS-1."
32192570
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"In the present study, bioinformatics analyses and luciferase assays were employed to show that miR-466 was able to directly target the 3 '-untranslated region of insulin receptor substrate 1 (IRS1) gene, negatively regulating the mRNA and the protein expression levels of IRS1 in OS cells."
30816452
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"Our results showed that IRS1 short hairpin RNAs can effectively suppress the expression of IRS1, and inhibit the phosphorylation of AKT in IRS1 pathway; reduce the expression of MMP2, MMP3, MMP13, and MMP14, decrease the expression of TNFRSF11B and RANKL (also known as tumor necrosis factor (ligand) superfamily, member 11), however increase the RANKL and TNFRSF11B ratio; decrease cell survival, proliferation, and mineralization, and impair the differentiation of MC3T3-E1 cells."
20525764
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"Decreased levels of insulin receptor substrates IRS-1 and IRS-2 levels were observed in neurons, and increased levels of inactivated phospho (Ser )IRS-1 and phospho (Ser )IRS-1 (Moloney et al., 2010)."
31068799
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"Therefore, we further revealed that miR-96 targets 3 ' UTRs of INSR and IRS-1 genes directly to suppress the expression of the INSR and IRS-1 protein, resulting in impaired insulin signaling and glycogen synthesis."
28036389
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"Downregulation of IRS-1 by IRS-1 siRNA decreased IRS-1 levels as expected and also the levels of phosphorylated GSK-3beta, which is downstream from IRS-1 in signal transduction."
24648009
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"IRS-1 siRNA specifically inhibited the expression of IRS-1 but not IRS-2, -3 and -4."
18501560
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"Transfection of IRS-1 siRNA efficiently reduced the level of IRS-1 in three lung cancer cell lines (i.e., A549, H157 and Calu-1) as detected by Western blotting (XREF_FIG A)."
28831455
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"These data suggest that miR-126 directly targets IRS-1 3 ' UTR and suppresses IRS-1 expression at the posttranscriptional level."
21464990
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"This study showed that (i) the expression of miR-1271 in hepatocytes is upregulated by palmitate; (ii) miR-1271 targets INSR and IRS-1 3 ' UTRs directly and downregulates the expression of INSR and IR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27613089
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"Transfection of IRS-1 siRNA efficiently reduced the level of IRS-1 in three lung cancer cell lines (i.e., A549, H157 and Calu-1) as detected by Western blotting."
28831455
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"Mechanistically, insulin receptor substrate 1 (Irs1) is a direct target of miR-191, and dysregulated IRS1 expression antagonizes STAT5 activation."
27634043