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Proteasome deubiquitinates USP14. 18 / 18
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"Tau degradation can also be promoted when deubiquitination by the proteasome associated deubiquitinating enzyme Usp14 is inhibited [XREF_BIBR]."
23994620
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"In ataxia (ax J) mice, profound neurological and synaptic defects result from a loss-of-function mutation in the proteasome associated deubiquitinating enzyme Usp14, which is required for recycling ubiquitin from proteasomal substrates."
22131412
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"Other inhibitors of the ubiquitin-proteasome system such as highly specific inhibitors of the proteasome associated deubiquitinating enzyme Usp14 could also show efficacy against aneuploid cells and thus could be used in the treatment of aneuploid cancers."
23374337
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"The Ub-proteasome system has its own quality control mechanisms, one of which is the proteasome associated deubiquitinating enzyme ubiquitin carboxyl-terminal hydrolase 14 (USP14)."
29981799
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"The functional activity of proteasome associated deubiquitinating enzyme USP14 was assessed in CD4 + T cells employing an active site probe as detailed in the experimental methods section."
23291607
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"A recent and exciting study for example explored the proteasome associated deubiquitinating enzyme USP14 as a target for proteasome enhancement [XREF_BIBR]."
22744791
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"We report here that a small molecule selected for its capacity to inhibit the proteasome associated deubiquitinating enzyme Usp14 strongly enhances substrate degradation by the proteasome in cells."
20829789
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"The proteasome associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions."
19726649
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"Similarly, IU1, an inhibitor of the proteasome-associated deubiquitinating enzyme USP14, was shown to reduce the replication of several flaviviruses [ 55 ]."
27648486
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"Here we show that IU1, a small-molecule inhibitor of the proteasome-associated deubiquitinating enzyme USP14, impairs viral replication."
22306365
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"Furthermore, since deubiquitinating enzymes associated with the proteasome are responsible for ubiquitin trimming from substrates targeted to the proteasome for degradation, and in light of growing evidence that the manner in which proteasome associated deubiquitinating enzymes, USP14 and UCH37, deubiquitinate substrates can in fact suppress and delay degradation and modulate proteasome function, we decided to next analyze the functional activity of the proteasome associated deubiquitinating enzyme USP14."
23291607
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"The proteasome associated deubiquitinating enzyme USP14 on one hand is functionally coupled with proteasomal activity and on the other hand a critical regulator of synaptic plasticity XREF_BIBR."
27883090
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"A potential candidate and NSCLC-related oncogene [ 52 , 53 ], proteasome-associated deubiquitinating enzyme USP14, was selected and monitored in SPC-A1 and NCI-H1650 cells with hsa-miR-124a knockdown [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29702194
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"The degradation of tau can be accelerated by proteasome activator Blm10 [37], as well as by inhibiting the proteasome-associated deubiquitinating enzyme Usp14 [70]."
30761219
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"B-AP15 simultaneously inhibits the proteasome associated deubiquitinating enzymes UchL5 and Usp14, whereas RA190 binds and inhibits the ubiquitin receptor subunit Rpn13 [XREF_BIBR, XREF_BIBR]."
25385277
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"Furthermore, inhibition of the proteasome associated deubiquitinating enzyme Usp14 promotes tau degradation [XREF_BIBR]."
24653662
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"The proteasome-associated deubiquitinating enzyme USP14 also binds and stabilizes AR in AR-positive BC cells including TNBC [114]; the highly likely possibility that the hypoxia-induced lncRNA KDM4A-AS1 binds and stimulates the de-ubiquitination of AR in TNBC also warrants investigation."
36012111
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"Moreover, in colorectal cancer (CRC), a proteasome-associated deubiquitinating enzyme, USP14, was discovered to be an attractive target for CRC immunotherapy."
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