IndraLab

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Proteasome deubiquitinates USP14. 15 / 15
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"Other inhibitors of the ubiquitin-proteasome system such as highly specific inhibitors of the proteasome associated deubiquitinating enzyme Usp14 could also show efficacy against aneuploid cells and thus could be used in the treatment of aneuploid cancers."
23374337
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"Tau degradation can also be promoted when deubiquitination by the proteasome associated deubiquitinating enzyme Usp14 is inhibited [XREF_BIBR]."
23994620
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"Additional targets which play a role in WM cell survival include TLR7, 8 and 9, proteasome associated deubiquitinating enzymes (USP14 and UCHL5), XPO1 and CRM1 and AURKA."
27825468
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"We report here that a small molecule selected for its capacity to inhibit the proteasome associated deubiquitinating enzyme Usp14 strongly enhances substrate degradation by the proteasome in cells."
20829789
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"A recent and exciting study for example explored the proteasome associated deubiquitinating enzyme USP14 as a target for proteasome enhancement [XREF_BIBR]."
22744791
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"Furthermore, inhibition of the proteasome associated deubiquitinating enzyme Usp14 promotes tau degradation [XREF_BIBR]."
24653662
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"The Ub-proteasome system has its own quality control mechanisms, one of which is the proteasome associated deubiquitinating enzyme ubiquitin carboxyl-terminal hydrolase 14 (USP14)."
29981799
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"B-AP15 simultaneously inhibits the proteasome associated deubiquitinating enzymes UchL5 and Usp14, whereas RA190 binds and inhibits the ubiquitin receptor subunit Rpn13 [XREF_BIBR, XREF_BIBR]."
25385277
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"The functional activity of proteasome associated deubiquitinating enzyme USP14 was assessed in CD4 + T cells employing an active site probe as detailed in the experimental methods section."
23291607
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"Furthermore, since deubiquitinating enzymes associated with the proteasome are responsible for ubiquitin trimming from substrates targeted to the proteasome for degradation, and in light of growing evidence that the manner in which proteasome associated deubiquitinating enzymes, USP14 and UCH37, deubiquitinate substrates can in fact suppress and delay degradation and modulate proteasome function, we decided to next analyze the functional activity of the proteasome associated deubiquitinating enzyme USP14."
23291607
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"The proteasome associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions."
19726649
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"In ataxia (ax J) mice, profound neurological and synaptic defects result from a loss-of-function mutation in the proteasome associated deubiquitinating enzyme Usp14, which is required for recycling ubiquitin from proteasomal substrates."
22131412
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"The proteasome associated deubiquitinating enzyme USP14 on one hand is functionally coupled with proteasomal activity and on the other hand a critical regulator of synaptic plasticity XREF_BIBR."
27883090
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"ISG15 conjugation may also help direct modified proteins to the proteasome, because the proteasome-associated deubiquitinating enzyme (DUB), USP14, can recognize ISG15-modified substrates, or it may function to attract components of the ubiquitin conjugation machinery.ISG15 plays a role in resistance to Ebola virus (also VSV and rabies virus) by blocking the activity of Nedd4 via ISGylation (reviewed in Sadler and Williams, 2008)."
19527883
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"Here we show that IU1, a small-molecule inhibitor of the proteasome associated deubiquitinating enzyme USP14, inhibits replication of several flaviviruses."
22306365