IndraLab

Statements

USP2 activates Cyclin. 9 / 9
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"Although, USP-2, as a deubiquitinating enzyme, is well known to prevent degradation of cyclins, including cyclin A1 and cyclin D1 (Kim et al., 2012; Shan et al., 2009), no studies have been reported r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26033248
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"Pharmacological inhibition of USP2 accelerates cyclin D1 degradation and leads to cell cycle arrest in several cancer cell lines among which the HCT116 colon cancer cell line and MCF7 breast cancer cell line."
30853938
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"USP2 directly interacts with cyclin D1 to perform deubiquitylation and thereby antagonize proteasome-dependent degradation of cyclin D1."
32006569
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"USP2 overexpression also increased the levels of two additional SKP2 substrates, cyclin D1 (12) and cyclin E2 (32) in H2170 cells with the low basal levels, but not in H1299 cells with high basal levels (Fig. 4A)."
34425107
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"The ubiquitin dependent proteolysis of cyclin D1 is antagonized by the deubiquitinating enzyme USP2, thus increasing cyclin D1 half-life."
30853938
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"APN can inhibit the expression of USP2 in tumor cells and promote the degradation of cyclin D1 [XREF_BIBR]."
33815885
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"Again, knockdown of USP2 in MCF-7 and PC3 cells significantly reduced the steady state levels of cyclin D1 protein (XREF_FIG, also in XREF_SUPPLEMENTARY) and also induced cell growth suppression (XREF_FIG)."
19917254
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"As expected, the half-life of cyclin D1 protein in MCF-7 cells was longer than that of other cancer lines such as HCT116; however, USP2 knockdown drastically reduced the cyclin D1 half-life from 60 to 20 minutes (XREF_FIG and XREF_SUPPLEMENTARY)."
19917254
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"Our results reveal that USP2 specifically modulates cyclin D1 function in vivo and demonstrate the importance of this regulation in human cancer cell growth."
19917254