IndraLab

Statements

USP2 activates Cyclin. 8 / 8
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"Again, knockdown of USP2 in MCF-7 and PC3 cells significantly reduced the steady state levels of cyclin D1 protein (XREF_FIG, also in XREF_SUPPLEMENTARY) and also induced cell growth suppression (XREF_FIG)."
19917254
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"Our results reveal that USP2 specifically modulates cyclin D1 function in vivo and demonstrate the importance of this regulation in human cancer cell growth."
19917254
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"USP2 directly interacts with cyclin D1 to perform deubiquitylation and thereby antagonize proteasome-dependent degradation of cyclin D1."
32006569
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"As expected, the half-life of cyclin D1 protein in MCF-7 cells was longer than that of other cancer lines such as HCT116; however, USP2 knockdown drastically reduced the cyclin D1 half-life from 60 to 20 minutes (XREF_FIG and XREF_SUPPLEMENTARY)."
19917254
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"Pharmacological inhibition of USP2 accelerates cyclin D1 degradation and leads to cell cycle arrest in several cancer cell lines among which the HCT116 colon cancer cell line and MCF7 breast cancer cell line."
30853938
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"APN can inhibit the expression of USP2 in tumor cells and promote the degradation of cyclin D1 [XREF_BIBR]."
33815885
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"Although, USP-2, as a deubiquitinating enzyme, is well known to prevent degradation of cyclins, including cyclin A1 and cyclin D1 (Kim et al., 2012; Shan et al., 2009), no studies have been reported r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26033248
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"The ubiquitin dependent proteolysis of cyclin D1 is antagonized by the deubiquitinating enzyme USP2, thus increasing cyclin D1 half-life."
30853938