IndraLab

Statements

USP14 activates cell growth. 20 / 20
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"Furthermore, USP14 depletion or USP14-specific inhibitor attenuates cell growth and migration in EC-derived cell lines or in mice."
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"In vitro experiment revealed that USP14 depletion markedly inhibited cell growth, cisplatin resistance, invasion and migration capabilities of HNSCC cells."
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"Depletion of USP14 or USP14-specific inhibitor suppresses cell growth in EC-derived cell lines and in mice."
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"USP14 promotes human aortic smooth muscle cell and A7r5 cell growth in vitro, and its inhibition or deficiency decreases the intimal area in the mice carotid artery ligation model."
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"It has been reported that USP14 expression was specifically upregulated in both lung adenocarcinoma cell lines and tumor tissues, and knockdown of USP14 expression significantly inhibited cell growth and cell cycle arrest in NSCLC cells XREF_BIBR."
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"Moreover, we also provide the evidence that USP14 depletion or USP14 inhibitor treatment abrogates cell growth in EC-derived cell lines and mice, suggesting that the interaction between USP14 and ERα may promote EC progression.Unopposed estrogen exposure is one of the main risk factors for type I EC."
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"USP14 depletion or IU1 treatment suppresses HCC cell growth in mice."
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"Third, we performed in vivo assays and confirmed that USP14 promoted EC cell growth."
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"Finally, we investigated whether exogenous expression of USP14 could enhance cell growth in HNSCC cells."
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"A previous study has highlighted that USP14 contributed to cell growth, migration, the activation of kinase and inflammasome, as well as inhibited autophagy and apoptosis in cancer cells 14."
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"Usp14 is largely contributed to enhancing cell proliferation, while itsoverexpression in CHO cells improves cell growth."
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"Inhibition of USP14 activity using the USP14 inhibitor IU1 or inhibition of USP14 expression using USP14-specific siRNA decreased gastric cancer cell growth."
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"Since we have observed that inhibition or knockdown of USP14 inhibited cell growth in LNcap cells, we further investigated whether USP14 inhibition or silence induces cell death of LNcap cells by measuring Annexin V-FITC and PI-positive cells with flow cytometry and by measuring PARP cleavage and p53 and Bax protein expression with western blot analyses."
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"It has been reported that USP14 expression was specifically upregulated in both lung adenocarcinoma cell lines and tumor tissues , and knockdown of USP14 expression significantly inhibited cell growth and cell cycle arrest in NSCLC cells12 ."
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"As shown in XREF_FIG, USP14 inhibition or silence failed to induce apoptosis or PARP cleavage but instead induced moderate decreases of p53 and Bax, suggesting that cell growth suppression mediated by USP14 inhibition or silence is through promoting cell proliferation, independent of cell death."
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"The knockdown of USP14 in HCC cells impairs cell growth and results in cell death."
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"Moreover, USP14 can activate phosphatidylinositol-3 kinase (PI3K) to induce cell growth via Wnt/β-catenin pathway (Huang et al., 2015; Zhang et al., 2020a), which also can contribute to the occurrence of drug resistance in CRC cells using USP22 (Miao et al., 2022)."
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"We found that the cell growth and colony formation ability of prostate cancer PC3 cells can be significantly enhanced by stable expression of USP14."
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"Moreover, knockdown of USP14 or USP14-specific inhibitor treatment significantly suppresses cell growth and migration in EC cell lines or in mice."
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"USP14 can also promote cell growth and inhibit cell apoptosis in AR-positive ERα-negative BCa (16)."
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