IndraLab

Statements

USP14 activates cell growth. 8 / 8
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"As shown in XREF_FIG, USP14 inhibition or silence failed to induce apoptosis or PARP cleavage but instead induced moderate decreases of p53 and Bax, suggesting that cell growth suppression mediated by USP14 inhibition or silence is through promoting cell proliferation, independent of cell death."
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"USP14 inhibition via administration of IU1 or USP14 specific siRNA and shRNA enhanced cell growth inhibition and apoptosis induction by enzalutamide in breast cancer cell lines in vitro and in vivo."
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"It has been reported that USP14 expression was specifically upregulated in both lung adenocarcinoma cell lines and tumor tissues, and knockdown of USP14 expression significantly inhibited cell growth and cell cycle arrest in NSCLC cells XREF_BIBR."
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"USP14 depletion or IU1 treatment suppresses HCC cell growth in mice."
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"The knockdown of USP14 in HCC cells impairs cell growth and results in cell death."
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"Since we have observed that inhibition or knockdown of USP14 inhibited cell growth in LNcap cells, we further investigated whether USP14 inhibition or silence induces cell death of LNcap cells by measuring Annexin V-FITC and PI-positive cells with flow cytometry and by measuring PARP cleavage and p53 and Bax protein expression with western blot analyses."
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"It has been reported that USP14 expression was specifically upregulated in both lung adenocarcinoma cell lines and tumor tissues , and knockdown of USP14 expression significantly inhibited cell growth and cell cycle arrest in NSCLC cells12 ."
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"Moreover, knockdown of USP14 or USP14-specific inhibitor treatment significantly suppresses cell growth and migration in EC cell lines or in mice."
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