IndraLab

Statements

USP1 binds UAF. 3 / 3
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"The USP1 and UAF complex is involved in the translesion synthesis through the deubiquitination of FANCD2 and FANCI [266]."
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"Inhibitors of the USP1 and UAF complex have been reported, such as ML323, developed based on a N-Benzyl-2-phenylpyrimidin scaffold, and C527."
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"Additional structural information modeling interaction sites for ML323 (as well other USP1 inhibitors) will help define which class of DUB inhibitors this drug falls into and will be instrumental moving forward to improve strategies for selectively targeting the UAF-USP1 complex and potentially other DUBs therapeutically.Key resources and reagents."
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