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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SHC binds IGF1R and IRS1. 2 / 2

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"Binding of the adaptor protein Shc and the docking protein IRS-1 to IGF-1R activates the MAPK and PI3/Akt/mTOR signaling pathways, respectively."

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"Moreover, partial or complete deletion of the C-terminal tail of the IGF-I receptor augments the reporter activity in a yeast two-hybrid assay quantifying the interaction between IRS-1 or Shc with the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...