IndraLab

Statements

MAPK1 phosphorylates RPS6KA1. 12 / 13
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"Immunolabeling of ERK1 and ERK2 and total and ERK1/2 Mediated Phosphorylation of RSK1 and MSK1."
26839717
sparser
"Compounds were assayed for their ability to inhibit the phosphorylation of p90Rsk-1 by ERK2 in HeLa cells."
22316156
reach
"Generation of the GTP bound form of Ras initiates a kinase cascade whereby Raf kinases activates MAP kinase kinase (MEK), which activates ERK1 and ERK2, which in turn phosphorylates RSK1 (reviewed in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10469565
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"Compounds were assayed for their ability to inhibit the phosphorylation of p90Rsk-1 by ERK2 in HeLa cells."
22316156
rlimsp
"Notably, extracellular signal regulated kinase 2 (ERK2) phosphorylates ribosomal S6 kinase 1 (RSK1), which promotes cellular growth."
25730857
sparser
"Based on in vitro kinase assays using purified proteins we demonstrated that ERK2 phosphorylates both RSK1 and MK2, while p38 and ERK5 are specific to MK2 ( xref )."
32649858
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"Of these, ERK2 (encoded by the gene MAPK1) was reported to increase the activity and phosphorylation of the oncoprotein RPS6KA1 (ribosomal protein S6 kinase, 90kDa, polypeptide A1), leading to cancer cell proliferation."
28388297
sparser
"The D319N D-domain mutation attenuated Rsk phosphorylation by ERK2 in KN6 γδTCR + progenitors cultured on ligand-expressing OP9 monolayers ( xref ); however, it did not disrupt the interaction of ERK2 with Egr1, as measured by co-immunoprecipitation ( xref )."
25526308
rlimsp
"PKA activity is also regulated by the interaction of other proteins with the regulatory (R) or catalytic (C) subunits of PKA, and a mechanism has been uncovered in which ribosomal S6 kinase (RSK1) interacts with either PKA subunit, depending on whether RSK1 has been phosphorylated and activated by extracellular signal-regulated kinase (ERK)."
16926362
reach
"Similarly, SF-3-030 had no apparent effects on ERK2 phosphorylation of the D-domain-containing substrate RSK1 or p38alpha-MAPK-mediated phosphorylation of the F-site-containing ATF2 protein, further supporting selective inhibition of ERK mediated phosphorylation events by SF-3-030 (XREF_FIG)."
25695333
signor
"Efficient rsk activation by erk requires its interaction through a docking site located near the c terminus of rsk"
12832467
sparser
"Specifically, it has been shown that the MAPKs ERK2 and p38α phosphorylate the kinases RSK1 or MK2, which have critical roles in the regulation of cell growth and apoptosis, respectively, and thus regulate central biological processes ( xref )."
32649858