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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CAMK2_complex leads to the phosphorylation of KCND2. 3 / 3

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"Similarly, CaMKII phosphorylated Kv4.2 upregulates both the expression level of Kv4.2 proteins and the peak current of Kv4.2 ( xref ; xref )."

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"It is possible that the increase in CaMKII activity due to CB expression is not sufficient to increase Kv4.2 phosphorylation to promote surface trafficking."

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"To test whether CaMKII phosphorylation of Kv4.2 affects channel biophysics, we expressed wild-type or mutant Kv4.2 and the K(+) channel interacting protein, KChIP3, with or without a constitutively active form of CaMKII in Xenopus oocytes and measured the voltage dependence of activation and inactivation in each of these conditions."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...