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BAP1 deubiquitinates Histone_H2B. 2 / 2

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"Loss of Asx in flies led to an increase in Ub-H2A levels without influencing other chromatin marks (H3K4 me3, H3K27me3), and assays using purified proteins found Asx stimulates Calypso activity towards Ub-AMC, and that Asx and Calypso and the human orthologs BAP1 and ASXL1 deubiquitinate H2A but not H2B in reconstituted nucleosomes [XREF_BIBR]."

23845989

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"Subsequent WB using anti-HA and anti- Flag antibodies showed that the BAP1 WT, but not a MT, deubiquitinated H2B in vivo."

23850490

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IndraLab

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BAP1 deubiquitinates Histone_H2B. 2 / 2

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