IndraLab

Statements

CYLD ubiquitinates DDX58. 6 / 6
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"K63 linked ubiquitination of RIG-I by TRIM25, MEX3C, and TRIM4 and deubiquitination of RIG-I by CYLD, USP3, and USP21 occur in the CARDs, whereas K63 linked ubiquitination by the RNF135 and Riplet occurs in the RD (K788), which has a positive effect on TRIM25 mediated K63 linked ubiquitination in the CARDs XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR."
31827068
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"CYLD was initially thought to inhibit IFN signaling by deubiquitinating the PRR, RIG1, and downstream kinases TBK-1 and IKKepsilon 44, but surprisingly, IFN response to vesicular stomatitis virus in CYLD knockout mice or cells from these mice was abrogated 45."
28295222
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"It was initially believed that CYLD inhibited IFN signaling by deubiquitinating the PRR, RIG-1, and downstream kinases TANK binding kinase 1 (TBK-1) and inhibitor of NF-kappaB kinase Epsilon (IKKEpsilon) 44; but, surprisingly, IFN response to vesicular stomatitis virus in CYLD knockout mice or cells from these mice was abrogated.45 On the basis of these reports, TRAF3 and CYLD may serve similar functions after viral infection, namely, to inhibit NF-kappaB and activate IFN."
28295222
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"Tumor suppressor protein cylindromatosis (CYLD) reduced the baseline Lys63 linked ubiquitination of RIG-I in uninfected cells XREF_BIBR."
25023063
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"Other DUBs that target the RIG-I and MDA5 pathway include CYLD and DUBA which target RIG-I and TRAF3 ubiquitination respectively (XREF_FIG)."
22435550
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"To the best of our knowledge, at least nine DUBs, A20, CYLD, USP3, USP5, USP14, USP15, USP21, USP25, and USP27X, have been proposed to counteract the K63linked ubiquitination of RIG-I and, thereby attenuate downstream signaling and IFN-b production ( Table 1 and Figure 3 ) (58, 76, 93) ."
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