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COPS6 activates cell population proliferation. 28 / 28
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"In summary , these findings demonstrated that downregulation of CSN6 expression could inhibit cell proliferation , migration and invasion ."
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"In human breast cancer MCF-7 cells, COPS6 overexpression stimulated p-AKT expression as well as the proliferation and malignant transformation of tumor cells, whereas knockdown of COPS6 caused opposite effects."
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"Our results demonstrated that CSN6 promoted the growth and proliferation capacities of cancer cells by G1 arrest."
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"Fig. 2 B shows that PDGF increased the protein level of CSN6 in a time-dependent manner, and peak time for 10 ng/ml PDGF up-regulation of CSN6 was 10 min, suggesting that CSN6 is up-regulated in PASMC[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overexpression of COPS6 or COPS9 increased HCC cell proliferation, migration, and invasion while knockdown suppressed these pro-tumorigenic and metastatic properties."
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"Through combinatorial effects on the MDM2-p53 signaling axis and now SKP2 mediated p57 Kip2 degradation, it is hypothesized that CSN6 overexpression can effectively promote cell proliferation by simultaneously relieving cell cycle restraints, apoptosis, senescence, and presumably p53 functions in DNA damage repair and cell metabolism, among other important tumor suppressive mechanisms."
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"In melanoma cells, CSN6 knockdown remarkably inhibited cell proliferation, tumorigenicity, migration, and invasion, whereas CSN6 recovery rescued the proliferative and metastatic abilities."
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"Furthermore, in CSN6-knockdown melanoma cells, UBR5 knockdown abrogated the effects caused by CSN6 silencing, suggesting that CSN6 activates the UBR5 and CDK9 pathway to promote melanoma cell proliferation and metastasis."
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"To investigate the cell viability of CSN6-knockdown melanoma cells, a 3-[4, -5-dimethylthiazol-2-yl]-2, -5-diphenyltetrazolium bromide (MTT) assay was conducted and revealed that CSN6 knockdown remarkably inhibited melanoma cell proliferation in vitro."
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"While knockdown of CSN6 attenuated the changes of β-TrCP and Cdc25A as well as PASMCs proliferation caused by PDGF."
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"CSN6 was overexpressed in human PTCs, and loss of CSN6 attenuated tumor proliferation and migration both in vitro and in vivo."
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"Thus, loss of CSN6 expression inhibits PTC proliferation and migration."
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"CSN6 recovery rescued the cell proliferation, migration, and invasion of CSN6-knockdown melanoma cells."
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"MTT and BrdU assays revealed that recovery of CSN6 expression rescued cell growth and proliferation."
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"Overexpression of CSN6 promoted processes of HCC cell proliferation, migration, and invasion, while these processes were inhibited when CSN6 was silenced."
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"This study revealed that CSN6 knockdown in melanoma cells inhibited cell proliferation in vitro and tumorigenicity in mice by inducing cell cycle arrest and that the anti-proliferative effect could be rescued by overexpressing CSN6 in CSN6-knockdown melanoma cells, suggesting that CSN6 has critical roles in triggering melanoma initiation and progression."
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"Loss of CSN6 attenuates tumor proliferation and migration."
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"The results suggested that, compared to the control, the silencing of CSN6 expression inhibited the proliferation of K1 and TPC-1 cells."
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"In melanoma cells , CSN6 knockdown remarkably inhibited cell proliferation , tumorigenicity , migration , and invasion , whereas CSN6 recovery rescued the proliferative and metastatic abilities ."
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"Results showed that COPS6 knockdown suppressed the promotion of proliferation, invasion, and migration of CRC cells induced by overexpressed ALDOA (Figures 8(a)–8(g))."
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"These results suggested that CSN6 may promote the cell proliferation and colony formation of GC cells."
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"In vitro and in vivo data showed that loss of CSN6 attenuated cell proliferation, migration, and invasion of PTC cells, confirming the vital function of CSN6 in PTC."
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"Furthermore, we investigated if CSN6 promoted cell proliferation via reducing p16 expression."
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"To determine the role of FASN in CSN6-promoted proliferation of CRC cells, we analyzed cellular growth of CSN6-expressing cells in the presence of FASN inhibitor orlistat (an FDA-approved anti-obesity drug)."
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"Second, functional assays showed that CSN6 inhibition significantly reduced both the motility and the proliferation of PTC cells."
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"In addition, studies shown that CSN6 has the function of deubiquitinase and promoted tumorigenesis, proliferation, metastasis and EMT by inhibiting substrates degradation [ 14–16 ]."
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"Here, we report that GBM tumors overexpressed CSN6 compared with normal brain tissues and that CSN6 promoted GBM cell proliferation, migration, invasion and tumorigenesis."
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"Our study provides important insights into the mechanisms that up-regulated CSN6 mediates PDGF-induced PASMCs proliferation and suggests that CSN6 might be an efficient target for PAH prevention and t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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