IndraLab

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COPS6 activates cell population proliferation. 20 / 20
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"COP9 signalosome subunit 6 mediates PDGF -induced pulmonary arterial smooth muscle cells proliferation."
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"Thus, loss of CSN6 expression inhibits PTC proliferation and migration."
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"MTT and BrdU assays revealed that recovery of CSN6 expression rescued cell growth and proliferation."
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"In human breast cancer MCF-7 cells, COPS6 overexpression stimulated p-AKT expression as well as the proliferation and malignant transformation of tumor cells, whereas knockdown of COPS6 caused opposite effects."
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"Second, functional assays showed that CSN6 inhibition significantly reduced both the motility and the proliferation of PTC cells."
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"In summary , these findings demonstrated that downregulation of CSN6 expression could inhibit cell proliferation , migration and invasion ."
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"Loss of CSN6 attenuates tumor proliferation and migration."
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"Through combinatorial effects on the MDM2-p53 signaling axis and now SKP2 mediated p57 Kip2 degradation, it is hypothesized that CSN6 overexpression can effectively promote cell proliferation by simultaneously relieving cell cycle restraints, apoptosis, senescence, and presumably p53 functions in DNA damage repair and cell metabolism, among other important tumor suppressive mechanisms."
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"CSN6 recovery rescued the cell proliferation, migration, and invasion of CSN6-knockdown melanoma cells."
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"In vitro and in vivo data showed that loss of CSN6 attenuated cell proliferation, migration, and invasion of PTC cells, confirming the vital function of CSN6 in PTC."
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"CSN6 was overexpressed in human PTCs, and loss of CSN6 attenuated tumor proliferation and migration both in vitro and in vivo."
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"To investigate the cell viability of CSN6-knockdown melanoma cells, a 3-[4, -5-dimethylthiazol-2-yl]-2, -5-diphenyltetrazolium bromide (MTT) assay was conducted and revealed that CSN6 knockdown remarkably inhibited melanoma cell proliferation in vitro."
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"Overexpression of CSN6 promoted processes of HCC cell proliferation, migration, and invasion, while these processes were inhibited when CSN6 was silenced."
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"Furthermore, in CSN6-knockdown melanoma cells, UBR5 knockdown abrogated the effects caused by CSN6 silencing, suggesting that CSN6 activates the UBR5 and CDK9 pathway to promote melanoma cell proliferation and metastasis."
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"This study revealed that CSN6 knockdown in melanoma cells inhibited cell proliferation in vitro and tumorigenicity in mice by inducing cell cycle arrest and that the anti-proliferative effect could be rescued by overexpressing CSN6 in CSN6-knockdown melanoma cells, suggesting that CSN6 has critical roles in triggering melanoma initiation and progression."
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"In melanoma cells , CSN6 knockdown remarkably inhibited cell proliferation , tumorigenicity , migration , and invasion , whereas CSN6 recovery rescued the proliferative and metastatic abilities ."
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"Here, we report that GBM tumors overexpressed CSN6 compared with normal brain tissues and that CSN6 promoted GBM cell proliferation, migration, invasion and tumorigenesis."
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"In melanoma cells, CSN6 knockdown remarkably inhibited cell proliferation, tumorigenicity, migration, and invasion, whereas CSN6 recovery rescued the proliferative and metastatic abilities."
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"In melanoma cells , CSN6 knockdown remarkably inhibited cell proliferation , tumorigenicity , migration , and invasion , whereas CSN6 recovery rescued the proliferative and metastatic abilities ."
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"The results suggested that, compared to the control, the silencing of CSN6 expression inhibited the proliferation of K1 and TPC-1 cells."
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