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UCHL5 activates MYC. 7 / 7
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"Additionally, UCHL5 promotes the mRNA and protein expression levels of CyclinD1, c-Myc, VEGF and Survivin (Fig. 4J, K, L and S1G)."
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"In another study on bladder cancer, UCHL5 was shown to promote tumor cell proliferation and migration by activating c-Myc through the AKT/mTOR signaling pathway [40]."
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"Conversely, UCHL5 overexpression significantly enhanced the protein profiles of p-PI3K, p-AKT, p-mTOR, c-Myc, SLC25A19, and ICAM5 in Western blotting (Figure 4I,K)."
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"Thus, our results reveal that UCHL5 can modulate the expression of downstream target genes (c-Myc, SLC25A19, and ICAM5) through the AKT/mTOR pathway."
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"UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling."
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"In contrast, UCHL5 overexpression in AN3-CA cells elevated the expression of β-catenin and its effector proteins (CyclinD1, C-myc, Survivin) and decreased cleaved-caspase3 (Figures 5D–F)."
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"As expected, UCHL5 overexpression induced the increase in β-catenin and its target genes CyclinD1, C-myc, and Survivin and the decrease in cleaved-caspase3 in AN3-CA cells, which were reversed by excessive XAV939 treatment (Figures 6A–C)."
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