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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

EIF3F activates Death. 2 / 2

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reach

"The same effect was reached in colorectal carcinoma cells lacking of p53 (HCT116 p53 -/-) in about 1 hour for MD 11 -K510R, 1.5 hours for MD 11 -NF and 3 hours for MD 11 -wt eIF3f, confirming that this cell line is more resistant than wild-type to the death stimulus and that p53 may play a role in eIF3f induced death (XREF_FIG)."

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reach

"For instance, one hour treatment of MD 11 -wt eIF3f induced 30% death in Colo857 and HCT116 p53 -/- and 50% in B16 and HCT116 p53 +/+, while MD 11 -K510R killed as expected 50% of Colo857 cells and 100% of the others."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...