IndraLab

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PDE4 inhibits CYLD. 3 / 3
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"As shown in XREF_FIG and XREF_SUPPLEMENTARY, inhibition of PDE4 using Rolipram still enhanced NTHi induced upregulation of CYLD in JNK1 depleted cells but not in JNK2 depleted cells, confirming the selective requirement of JNK2 in mediating PDE4B-depenent negative regulation of CYLD expression."
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"Having demonstrated that inhibition of PDE4 enhanced upregulation of CYLD and suppressed NTHi induced inflammation, it is still unclear whether inhibition of PDE4 suppresses inflammation via upregulating the expression of CYLD, a key negative regulator of inflammation, or via inhibiting key positive regulators of inflammation, for example, IKKbeta."
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"Interestingly, PDE4 inhibition using Rolipram no longer enhanced NTHi induced upregulation of CYLD and suppressed inflammation in HMEEC cells that had been already pretreated with SP600125 (XREF_FIG)."
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