IndraLab

Statements

USP10 inhibits FUT1. 3 / 3
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"However, our results using USP10 functional mutants indicated that ROS inhibition by USP10 is dispensable for USP10 to inhibit apoptosis of HSCs."
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"Since aberrant ROS production has been shown to be a critical apoptosis inducer of HSCs under basal and stress conditions ( xref ), it was initially assumed that USP10 inhibits apoptosis of HSCs by inhibiting ROS production."
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"These results suggest that inhibition of HSC apoptosis is a function of USP10 to maintain the number of HSCs in FL, and that USP10 selectively inhibits apoptosis of HSCs, MPPs, and HPCs but not more differentiated LCPs."
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