IndraLab

Statements

CHEK2 phosphorylates TP53 on S366. 7 / 7
1 2 | 4
signor
"The cell cycle checkpoint kinases CHK1 and CHK2 have been shown to phosphorylate multiple sites in the N-terminal domain of p53, consequently leading to p53 stabilization and activation. Phosphorylation of at least three of these sites, Ser366, Ser378, and Thr387, was induced by DNA damage."
15659650
signor
"Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53."
10673501
reach
"ATM dependent dephosphorylation of p53 at S376 and Chk1 and Chk2 dependent phosphorylation of p53 at S378, S366 and T387 generate 14-3-3 binding sites in vivo."
19933256
reach
"Chk2 is known to mediate phosphorylation of p53 at Ser 366 and Ser 378 in response to genotoxic stresses XREF_BIBR."
21187893
reach
"However, during the later stages, CHK2 may contribute to p53 phosphorylation at Ser366 and Ser378, resulting in p53 degradation through the ubiquitin-proteasome pathway and blocking of p53 mediated apoptosis [XREF_BIBR] and the EBV protein kinase BGLF4 contributes to p27 phosphorylation and its ubiquitin-proteasome dependent degradation [XREF_BIBR]."
21526939
biopax:phosphositeplus
No evidence text available
reach
"The Chk1 and Chk2 kinases phosphorylate p53 at S366, S378 and T387."
19933256