IndraLab

Statements

ZEB1 binds USP10. 5 / 5
2 | 3
sparser
"Regulation of the USP10-ZEB1 interaction by MEK-ERK signaling was shown whereby constitutive activation of ERK can phosphorylate USP10 at Ser236 to impair its interaction with ZEB1 and enable ZEB1 protein stabilization."
36940483
sparser
"Implications: The MEK-ERK regulated interaction of USP10 with ZEB1 can promote the proteasomal degradation of ZEB1 and thereby suppress its demonstrated ability to mediate tumor metastasis."
36940483
biogrid
No evidence text available
29119051
biogrid
No evidence text available
29119051
sparser
"Conversely, MEK-ERK inhibition blocked USP10 phosphorylation and enhanced the USP10-ZEB1 interaction shown to suppress ZEB1-mediated tumor cell migration and metastasis."
36940483