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SRC phosphorylates AKT on tyrosine. 24 / 24
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"In addition, YAP1 is serine phosphorylated by AKT and JNK and tyrosine phosphorylated by Yes and Src and Abl (Basu et al., 2003; Danovi et al., 2008; Levy et al., 2008; Piccolo et al., 2014; Zhao et a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, these results suggest APPL1 reduces the amount of active Akt in cells by inhibiting tyrosine phosphorylation of Akt by Src."
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"Akt tyrosine phosphorylation is mediated by the non receptor tyrosine kinase Src."
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"The PKB Y315 residue, which is known to be phosphorylated by Src tyrosine kinase, was also a major site of phosphorylation by RET and PTC."
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"Because tyrosine phosphorylation of Akt by Src was recently shown to be important in both the activation of Akt and its biological function (Chen ; Choudhury ; Bouchard ), we hypothesized that Src-mediated tyrosine phosphorylation of Akt was critical for its effects on migration."
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"We began to test this hypothesis by assessing tyrosine phosphorylation of Akt by Src in HT1080 cells."
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"Our results support a working model in which the adaptor protein APPL1 inhibits cell migration and adhesion dynamics through a mechanism involving the Src-mediated tyrosine phosphorylation of Akt."
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"Moreover, APPL1 inhibits the ability of Akt to promote migration by impairing Src mediated tyrosine phosphorylation of Akt."
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"Then Src phosphorylates Akt at Y residue(s), which triggers Akt A-loop (T308) and HM (S473) phosphorylation by PDK1 and mTORC2 xref ."
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"We began to test this hypothesis by assessing tyrosine phosphorylation of Akt by Src in HT1080 cells."
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"Interestingly, our results in XREF_FIG indicate that OxPAPC mediated tyrosine phosphorylation of Akt (by Src and Fyn) (XREF_FIG) is S1P 1 receptor independent."
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"In addition, APPL1 significantly decreases the tyrosine phosphorylation of Akt by the nonreceptor tyrosine kinase Src, which is critical for Akt-mediated cell migration."
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"In our study, inhibition of Src with PP2 led to a decrease in the tyrosine phosphorylation of Akt, whereas promotion of Src activity, through expression of CA-Src, increased the level of tyrosine phosphorylated Akt, indicating that Src can tyrosine phosphorylate Akt."
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"Tyrosine phosphorylation of Akt by Src enhances the activity of Akt."
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"Thus, APPL1 can inhibit Akt function by reducing the tyrosine phosphorylation of Akt by Src, which hinders cell migration."
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rlimsp
"APPL1 regulates the tyrosine phosphorylation of Akt by Src."
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"Because tyrosine phosphorylation of Akt by Src was recently shown to be important in both the activation of Akt and its biological function, we hypothesized that Src mediated tyrosine phosphorylation of Akt was critical for its effects on migration."
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"In addition, APPL1 significantly decreases the tyrosine phosphorylation of Akt by the nonreceptor tyrosine kinase Src, which is critical for Akt mediated cell migration."
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"Thus, APPL1 can inhibit Akt function by reducing the tyrosine phosphorylation of Akt by Src, which hinders cell migration."
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rlimsp
"However, more recent work indicates that Akt activity is also regulated by tyrosine phosphorylation, which is carried out by Src (Chen )."
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"Tyrosine phosphorylation of Akt by Src enhances the activity of Akt."
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"APPL1 regulates the tyrosine phosphorylation of Akt by Src."
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"Upon EGF stimulation, Akt is phosphorylated at Tyr315 and Tyr326 by Src or protein tyrosine kinase 6 (PTK6), a Src related tyrosine kinase [XREF_BIBR, XREF_BIBR]."
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"Thus, these results suggest APPL1 reduces the amount of active Akt in cells by inhibiting tyrosine phosphorylation of Akt by Src."
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