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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SCN5A inhibits BrS. 2 / 2

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"This might point to the fact that loss-of-function mutations in SCN5A and GPD1L might not be sufficient to cause BrS but could act like a revelatory factor such as a sodium channel blocker challenge."

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"In such cases, cardiac fibrosis contributes to the pathogenesis in varying degrees.Diffuse ventricular myocardial fibrosis in the right ventricular outflow tract was observed in patients with BrS.4 12 The missense mutation S910L was previously reported by Kapplinger and colleagues9 in a case of BrS, which was caused by the loss of function of SCN5A."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...