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"In whole-cell voltage clamp studies we found : 1) 60 muM A-935142 enhanced hERG current in the presence of 150 muM sotalol (57.5 +/-5.8%) to a similar extent as seen with A-935142 alone (55.6 +/-5.1%); 2) 150 muM sotalol blocked hERG current in the presence of 60 muM A-935142 (43.5 +/-1.5%) to a similar extent as that seen with sotalol alone (42.0 +/-3.2%) and 3) during co-application, hERG current enhancement was followed by current blockade."