IndraLab
Statements
sparser
"This picture was supported by another study regarding the rectification mechanism of BK channels in the presence of β3, in which the authors suggested that the extracellular loop of the β3 subunit associates with the Slo1 subunit near the axis of the permeation pathway to form gates blocking ion permeation (Zeng et al., xref )."
sparser
"The major step in this endeavor will represent the development of novel LCA analogs which, while keeping selectivity on β1 subunit-containing channels complexes over homomeric slo1 or heteromeric channels resulting from association of slo1 with β2, β3 or β4 subunits, show equal or better potency and efficacy than LCA, and lack structural features responsible for widespread physiological effects of LCA and related steroids."