IndraLab

Statements

FNT farnesylates KRAS. 8 / 8
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reach
"N- and K-RAS can be farnesylated and geranylgeranylated by FTase and GGTase I, respectively [31]."
38201517
reach
"Siprashvili et al. recorded the sequestration of the mutant K-Ras oncoprotein in the cytoplasm via direct binding by SNORD50A/B, which significantly reduced the farnesylation of K-Ras by FTase, diminishing tumorigenesis facilitated by the Ras-ERK1/2/MAPK pathway (Figure 4a) [107]."
38474168
reach
"Given the critical role of prenylation for KRAS membrane association and neoplastic transformation, and farnesylation of KRAS by FTase is the first step in the KRAS post-translational modification, FTase is the ideal target for KRAS-driven cancers."
33122197
sparser
"After translation, KRAS is farnesylated by farnesyltransferase at the CAAX cysteine [ 16 ]."
34303932
sparser
"Given the critical role of prenylation for KRAS membrane association and neoplastic transformation, and farnesylation of KRAS by FTase is the first step in the KRAS post-translational modification, FTase is the ideal target for KRAS-driven cancers."
33122197
sparser
"Siprashvili et al. recorded the sequestration of the mutant K-Ras oncoprotein in the cytoplasm via direct binding by SNORD50A/B, which significantly reduced the farnesylation of K-Ras by FTase, diminishing tumorigenesis facilitated by the Ras-ERK1/2/MAPK pathway ( xref a) [ xref ]."
38474168
sparser
"UCF 116-B inhibited farnesylation of viral K-Ras by bovine brain FTase with IC 50 values of 1.2 and 0.6 μg/mL, respectively."
36240545
sparser
"FTase enzyme inhibition was determined by inhibition of farnesylation of human K-Ras by human FTase, as previously described."
17127066