IndraLab

Statements

PSMD14 activates Proteasome. 13 / 13
| 3 10
reach
"Important here is that while our CRISPR-dCas9 mediated upregulation of Psmd14 expression has been previously shown to stimulate proteasome activity in the brain [25], this was only assessed with the chymotrypsin form of activity."
35282800
eidos
"The PSMD14 inhibitor , capzimin ( CZM ) , inhibits proteasome activity but differs from the 20S proteasome subunit-inhibiting bortezomib ( Bz ) in that it does not induce aggresome formation or Nrf1 upregulation , which underlie Bz resistance in cancer cells ."
35269789
reach
"The significantly upregulated genes encoding proteasome components (PSMC1, PSMD1, PSMD14, PSMD3, PSMD2, PSMD8) belong to multiple categories, indicating that numerous cellular processes in skeletal muscle from UCP1 KI pigs might be regulated by the degradation of ubiquitinated target proteins through coordinated functions of genes associated with these four GO terms (proteasome complex, endopeptidase complex, proteasome regulatory particle, proteasome accessory complex) (Figure 4C)."
35096834
reach
"To more specifically test for any requirement of the zinc metalloproteinase motif of Poh1 to support cell viability and proteasome function, we developed a RNAi complementation strategy."
17237285
eidos
"Additionally , in order to reduce proteasome activity , which was also elevated at baseline ( Figure 2B ) , we multiplexed with a guide RNA against Psmd14 ; this subunit of the proteasome is essential for proteasome assembly and function and upregulation of Psmd14 in invertebrates has been shown to increase proteasome activity ( Tonoki et al ., 2009 ) ."
33609735
reach
"Pharmacological inhibition of PSMD14(Rpn11) with O-phenanthroline (OPA) blocks cellular proteasome function, induces apoptosis in MM cells, and overcomes resistance to proteasome inhibitor bortezomib [26]."
38863002
reach
"In other biological models, it has been showed that the proteasome activity is modulated by changes in RPN11 levels or activity ( Tonoki et al., 2009 ; Saunier et al. 2013 ; Li et al., 2018 )."
34627761
eidos
"As SKP2 reduction was observed after PSMD14 knockdown ( data not shown ) , the inhibition of proteasome activity by PSMD14 knockdown and the inhibition of p27 degradation through SKP2 reduction may cause the accumulation of p27 protein in melanoma ."
| PMC
reach
"Recently, a specific inhibitor of PSMD14, capzimin, has been discovered to inhibit PSMD14 and proteasome function, and then suppress the proliferation of tumor cells [ 56 , 57 ], providing a novel ins[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29331416
reach
"By contrast, the ATP independent activity of Poh1 described here could allow the proteasome to spare proteins modified with K63 linked chains from degradation."
19295498
reach
"This observation is in line with our finding (not shown) that targeted RNAi-mediated KD of 20S (Prosβ5, Prosα7) or 19S (Rpn11) proteasomal genes in either muscle or nervous tissues caused (likewise ubiquitous proteasome KD) developmental lethality in larval and early pupal stages.As mentioned, our proteomics analyses after proteasome KD also revealed alterations in the expression of metabolic proteins."
31002009
reach
"PSMD14 is considered an enzyme that can cleave unnecessary proteins by binding and activating the 20S proteasome to form 26S proteasomes (Spataro & Buetti-Dinh, 2022)."
36632137
reach
"The overexpression of the 19S RP subunit Rpn11 enhanced proteasome function and suppressed neurodegenerative pathology caused by the accumulation of ubiquitinated proteins and polyQ protein accumulation in the compound eye (38)."
38348509