IndraLab

Statements

PSMD14 activates Proteasome. 6 / 6
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"The PSMD14 inhibitor , capzimin ( CZM ) , inhibits proteasome activity but differs from the 20S proteasome subunit-inhibiting bortezomib ( Bz ) in that it does not induce aggresome formation or Nrf1 upregulation , which underlie Bz resistance in cancer cells ."
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"The significantly upregulated genes encoding proteasome components (PSMC1, PSMD1, PSMD14, PSMD3, PSMD2, PSMD8) belong to multiple categories, indicating that numerous cellular processes in skeletal muscle from UCP1 KI pigs might be regulated by the degradation of ubiquitinated target proteins through coordinated functions of genes associated with these four GO terms (proteasome complex, endopeptidase complex, proteasome regulatory particle, proteasome accessory complex) (Figure 4C)."
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"By contrast, the ATP independent activity of Poh1 described here could allow the proteasome to spare proteins modified with K63 linked chains from degradation."
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"To more specifically test for any requirement of the zinc metalloproteinase motif of Poh1 to support cell viability and proteasome function, we developed a RNAi complementation strategy."
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"Additionally , in order to reduce proteasome activity , which was also elevated at baseline ( Figure 2B ) , we multiplexed with a guide RNA against Psmd14 ; this subunit of the proteasome is essential for proteasome assembly and function and upregulation of Psmd14 in invertebrates has been shown to increase proteasome activity ( Tonoki et al ., 2009 ) ."
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"As SKP2 reduction was observed after PSMD14 knockdown ( data not shown ) , the inhibition of proteasome activity by PSMD14 knockdown and the inhibition of p27 degradation through SKP2 reduction may cause the accumulation of p27 protein in melanoma ."
| PMC