IndraLab

Statements

MDM2 activates USP7. 7 / 7
| 7
reach
"In vitro and in cancer cell lines, p300 mediated acetylation of MDM2 on Lys 182 and Lys 185 enabled HAUSP to bind, presumably deubiquitinate, and stabilize MDM2."
28196907
reach
"HAUSP plays pivotal roles in the stability of p53 and MDM2, raising HAUSP as a potential therapeutic target for tuning p53 mediated anti-tumor activity."
26077642
reach
"Both USP2 and USP7 and HAUSP target MDM2 and lead to its degradation XREF_BIBR."
27665737
reach
"P22077 downregulated USP7 targets MDM2, claspin, and Chk1 [XREF_BIBR] and inhibited neuroblastoma growth [XREF_BIBR], and P50429 inhibited HCT116 proliferation [XREF_BIBR, XREF_BIBR]."
30897496
reach
"Since MDM2 is the preferred target of USP7 under unstressed conditions [XREF_BIBR, XREF_BIBR], then logically, suppression of USP7 should destabilize MDM2."
23151129
reach
"These findings suggest that p300 mediated MDM2 acetylation within the NLS domain enables HAUSP to be recruited to the acidic domain, leading to deubiquitination of MDM2 (XREF_FIG)."
28196907
reach
"It has been shown that Mdm2 is the primary target of USP7 mediated stabilization."
23555268