IndraLab

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USP28 activates MYC. 40 / 41
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"This protein inhibits the development of malignant gliomas by antagonizing USP28-induced c-Myc stability and reducing the half-life of c-Myc."
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"USP28 can counteract the activity of FBW7 and promote c-MYC stability in cancer cells."
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"Yang et al (80) found that circFBXW7 encodes a novel 21 kDa protein, FBXW7-185aa, and that FBXW7-185aa inhibits the formation of malignant glioblastoma through antagonizing USP28-induced c-Myc stability by reducing the half-life of c-Myc."
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"USP28 antagonizes the Ub-dependent degradation of c-myc, as well as c-Jun and Notch, by targeting the Ub ligase Fbw7, thereby stabilizing the HIF-1α transcription factor [66] ."
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"Upregulation of FBXW7-185aa inhibited proliferation and cell cycle progression and reduced the half-life of c-Myc by antagonizing USP28 induced c-Myc stabilization in glioblastoma, while knockdown of FBXW7-185aa promoted malignant phenotypes in vitro and in vivo [XREF_BIBR]."
| PMC
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"Interestingly, Yang et al. [75] identified a circular RNA encoding circ-FBXW7, whose expression in GBM samples was lower compared to the surrounding normal tissue, being capable of antagonizing the stabilization of the oncoprotein c-MYC initiated by the deubiquitinase USP28; circ-FBXW7 expression was linked to greater survival in patients."
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"Therefore, FBXW-185aa prevents FBXW7alpha induced degradation by antagonizing USP28 induced c-Myc stabilization."
32509801
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"In this study FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28 induced c-Myc stabilization."
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"FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization."
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"Here, using murine genetic models, we determined that USP28 antagonizes the ubiquitin dependent degradation of c-MYC, a known USP28 substrate, as well as 2 additional oncogenic factors, c-JUN and NOTCH1, in the intestine."
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"Deletion of USP28 downregulated MYC protein, whereas knockout of a related DUB USP25 did not affect MYC levels (Supplementary Figure S1B)."
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"Cycloheximide assays confirmed that USP28 knockout decreased MYC protein stability (Supplementary Figure S1C)."
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"FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28 induced c-Myc stabilization."
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"This peptide supposes to repress glioma malignancy through USP28 induced c-Myc stabilization."
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"FBXW7-185aa, a protein encoded by Circ-FBXW7 with no clear subcellular localization identified to date, reduces the half-life of c-Myc by antagonizing USP28-induced stabilization of c-Myc, thereby impeding the development of malignant gliomas [99]."
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"For instance, the role of ciRS-7 on the development of Parkinson's disease (PD) has been well studied as miR-7 sponge.19, 36 In addition, the dysfunction of ciRS-7-miRNA-7-UBE2A circuit contributed to the development of sporadic Alzheimer's disease (AD).37, 38 More importantly, down regulation of CDR1as in mammalian cell culture modified cell migration and over-expression in the zebrafish brain leaded to brain developmental defects.39 Recently, circ-FBXW7 was identified in Glioma and positively with glioblastoma patient overall survival, strikingly, circ-FBXW7 could encode a novel 21-kDa protein termed FBXW7-185aa that reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization and served as tumor suppressor.40 Regulation of skeletal and cardiac muscle development and function by circRNAs."
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"USP28 could modulate the lifespan of c-Myc, c-JUN, Notch1, and ΔNp63 through erasing ubiquitin modifications from them [ 8 , 9 ]."
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"USP28 has also been reported to antagonize ubiquitin-dependent degradation of the oncogene product MYC as well as JUN and Notch ."
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"A study by Zhang et al demonstrated that circ-FBXW7 encodes FBXW7-185aa, a protein consisting of 185 amino acids that can significantly inhibit tumour cell processes in vivo and reduce the half-life of c-Myc by antagonizing the stabilization effect of c-Myc induced by USP28."
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"Since FBW7gamma lacks the USP28 interaction motif of FBW7alpha, Usp28 selectively antagonize nucleoplasmic MYC degradation while not affecting nucleolar degradation."
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"In particular, FBXW7-185aa, shown in Fig. 3 , reduces the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization thus inhibiting the proliferation of glioblastoma, whereas EIF6-224aa pro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In one study, FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28 induced c-Myc stabilization 43."
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"55 Usp28 mediated Myc stabilization is required for tumor cell proliferation and has shown clinical significance in non small cell lung cancer, breast cancer, intestinal cancer, gliomas, and bladder cancer."
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"CircFBXW7-185aa, a novel protein, could inhibit glioma genesis by antagonizing USP28-induced c-myc stabilization to shorten the half-life of c-myc [ 177 ]."
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"Moreover, FBXW7-185aa can competitively bind USP28 to antagonizing USP28-induced c-Myc stabilization, thus suppressing glioma cell proliferation and cell cycle [74] ."
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"Knockdown of Usp28 results in a decrease of c-MYC while overexpression of the enzyme and leads to stabilization of the transcription factor ."
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"Circ-FBXW7, highly expressed in normal human brain, has been reported to encode a novel 21-kDa protein, named FBXW7-185aa, that reduces the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization, thus acting as tumor suppressor in glioblastoma cells (34)."
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"The FBXW7-185aa protein can reduce the half-life of the c-Myc oncoprotein, which is known to regulate the transcription of numerous genes and pathways, via antagonizing ubiquitin carboxyl-terminal hydrolase 28 (USP28) induced c-Myc stabilization in glioma cells (Yang et al., 2018)."
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"Independently, USP28 has been reported to modulate the activity of the Myc proto-oncogene [XREF_BIBR]."
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"The encoded protein of circ-FBXW7, FBW7-185aa, inhibits cell proliferation and cell cycle acceleration via antagonizing USP28-mediated c-Myc stabilization."
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"In a previous study, circFBXW7 was found to be downregulated in glioma, where it is translated into a 185-amino acid (aa) protein (FBXW7-185aa) that competitively interacts with the deubiquitinating enzyme USP28, preventing USP28 from binding to FBXW7 and antagonizing USP28 induced c-Myc stabilization."
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"Inhibitory effects on glioma proliferation and cell-cycle acceleration are instead mediated by a 185 amino acid protein encoded from circFBXW7 (FBXW7-185aa) which reduces the half life of c-Myc by antagonizing USP28-induced c-Myc stabilization, suggesting new prognostic implications for glioma patients [127]."
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"FBXW7-185aa can antagonize ubiquitin carboxyl-terminal hydrolase 28-induced c-Myc stabilization to reduce the half-life of c-Myc, inhibiting cell proliferation (59)."
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"A previous study in glioma implicated that the short protein FBXW7-185aa interacts with the deubiquitinating enzyme USP28, preventing USP28 from binding to FBXW7 and antagonizing USP28 induced c-Myc stabilization [XREF_BIBR]."
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"Knockdown of either Usp28 or Usp36 downregulates Myc and suppresses cancer cell proliferation in cell culture."
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"The protein FBXW7-185aa functions as a tumor suppressor by competitively binding with USP28, and preventing USP28 binding to FBXW7α, subsequently inhibiting USP28-induced c-myc stabilization."
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"Furthermore, Zhang et al. reported that circ-FBXW7 could encode FBXW7-185aa, which shortens the half-life of c-Myc by antagonizing USP28-induced stabilization of c-Myc, illustrating how circRNAs can modulate key oncogenic pathways [138]."
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"Besides, knockdown of USP28 blocked the effect of c-Myc on activation of ataxia telangiectasia-mutated and ataxia telangiectasia and Rad3 related DNA damage checkpoint after irradiation."
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"USP28 increases the stabilization of c-MYC and cyclin E1, thereby promoting the proliferation of cancer cells [39]."
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"Additionally, a deubiquitinase, USP28, has been reported to antagonize ubiquitin dependent proteasomal degradation of c-Myc."
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