IndraLab

Statements

USP28 activates MYC. 26 / 26
1 | 1 1 23
reach
"USP28 has also been reported to antagonize ubiquitin-dependent degradation of the oncogene product MYC as well as JUN and Notch ."
28959952
reach
"FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28 induced c-Myc stabilization."
28903484
reach
"This peptide supposes to repress glioma malignancy through USP28 induced c-Myc stabilization."
32977537
reach
"Circ-FBXW7, highly expressed in normal human brain, has been reported to encode a novel 21-kDa protein, named FBXW7-185aa, that reduces the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization, thus acting as tumor suppressor in glioblastoma cells (34)."
36338714
reach
"Since FBW7gamma lacks the USP28 interaction motif of FBW7alpha, Usp28 selectively antagonize nucleoplasmic MYC degradation while not affecting nucleolar degradation."
19489724
reach
"In a previous study, circFBXW7 was found to be downregulated in glioma, where it is translated into a 185-amino acid (aa) protein (FBXW7-185aa) that competitively interacts with the deubiquitinating enzyme USP28, preventing USP28 from binding to FBXW7 and antagonizing USP28 induced c-Myc stabilization."
31536884
trips
"FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization."
28903484
reach
"A study by Zhang et al demonstrated that circ-FBXW7 encodes FBXW7-185aa, a protein consisting of 185 amino acids that can significantly inhibit tumour cell processes in vivo and reduce the half-life of c-Myc by antagonizing the stabilization effect of c-Myc induced by USP28."
32319596
reach
"Here, using murine genetic models, we determined that USP28 antagonizes the ubiquitin dependent degradation of c-MYC, a known USP28 substrate, as well as 2 additional oncogenic factors, c-JUN and NOTCH1, in the intestine."
24960159
reach
"Upregulation of FBXW7-185aa inhibited proliferation and cell cycle progression and reduced the half-life of c-Myc by antagonizing USP28 induced c-Myc stabilization in glioblastoma, while knockdown of FBXW7-185aa promoted malignant phenotypes in vitro and in vivo [XREF_BIBR]."
| PMC
signor
"Usp28, an ubiquitin-specific protease, binds to myc through an interaction with fbw7alpha, an f-box protein that is part of an scf-type ubiquitin ligase. Therefore, it stabilizes myc."
17558397
reach
"The protein FBXW7-185aa functions as a tumor suppressor by competitively binding with USP28, and preventing USP28 binding to FBXW7α, subsequently inhibiting USP28-induced c-myc stabilization."
30111313
reach
"Independently, USP28 has been reported to modulate the activity of the Myc proto-oncogene [XREF_BIBR]."
23712866
reach
"A previous study in glioma implicated that the short protein FBXW7-185aa interacts with the deubiquitinating enzyme USP28, preventing USP28 from binding to FBXW7 and antagonizing USP28 induced c-Myc stabilization [XREF_BIBR]."
33466455
eidos
"Knockdown of Usp28 results in a decrease of c-MYC while overexpression of the enzyme and leads to stabilization of the transcription factor ."
19489724
reach
"Besides, knockdown of USP28 blocked the effect of c-Myc on activation of ataxia telangiectasia-mutated and ataxia telangiectasia and Rad3 related DNA damage checkpoint after irradiation."
30206969
reach
"In this study FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28 induced c-Myc stabilization."
32528957
reach
"USP28 has also been reported to antagonize ubiquitin-dependent degradation of the oncogene product MYC as well as JUN and Notch 105 ."
28959952
reach
"Independently, USP28 has been reported to modulate the activity of the Myc proto-oncogene [126]."
23712866
reach
"Additionally, a deubiquitinase, USP28, has been reported to antagonize ubiquitin dependent proteasomal degradation of c-Myc."
26771234
reach
"In one study, FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28 induced c-Myc stabilization 43."
31119043
reach
"Interestingly, Yang et al. [75] identified a circular RNA encoding circ-FBXW7, whose expression in GBM samples was lower compared to the surrounding normal tissue, being capable of antagonizing the stabilization of the oncoprotein c-MYC initiated by the deubiquitinase USP28; circ-FBXW7 expression was linked to greater survival in patients."
33665742
reach
"USP28 can counteract the activity of FBW7 and promote c-MYC stability in cancer cells."
29415985
reach
"The FBXW7-185aa protein can reduce the half-life of the c-Myc oncoprotein, which is known to regulate the transcription of numerous genes and pathways, via antagonizing ubiquitin carboxyl-terminal hydrolase 28 (USP28) induced c-Myc stabilization in glioma cells (Yang et al., 2018)."
30483132
reach
"Therefore, FBXW-185aa prevents FBXW7alpha induced degradation by antagonizing USP28 induced c-Myc stabilization."
32509801
reach
"55 Usp28 mediated Myc stabilization is required for tumor cell proliferation and has shown clinical significance in non small cell lung cancer, breast cancer, intestinal cancer, gliomas, and bladder cancer."
33692331