IndraLab

Statements

USP1 inhibits PC. 5 / 5
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"Collectively, we showed that USP1 interacts with KDM4A and promotes its deubiquitination, ultimately leading to KDM4A stabilization, and inhibition of USP1 promotes the response of PC cells to therapeutic agent enzalutamide."
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"These results reveal that targeting USP1 promotes PC cell response to therapeutic agent enzalutamide."
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"Notably, upregulation of KDM4A expression with high USP1 expression was observed in most prostate tumors and inhibition of USP1 promotes PC cells response to therapeutic agent enzalutamide."
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"In future, we will test whether inhibition of USP1 in enzalutamide resistant cells could promote the PC cell response to enzalutamide."
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"Furthermore, we found that USP1 knockdown reduced tumorigenesis and promoted PC cell response to therapeutic agent enzalutamide in a KDM4A dependent manner."
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