IndraLab

Statements

USP14 increases the amount of AR. 4 / 4
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"In the rescue experiments, IU1 induced AR downregulation can be reversed by proteasome inhibitor bortezomib (Velcade), suggesting that reduction of AR protein levels by the inhibition of USP14 depends on proteasome activity."
28151478
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"Indeed, we found that inhibition or reduction of USP14 dramatically decreased the protein levels of AR and PSA (a target gene of AR)."
28151478
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"We found that dual inhibitors of USP14 and UCHL5 such as b-AP15 [XREF_BIBR] and auranofin [XREF_BIBR] reduced AR protein level in both prostate and breast cancer cells."
29353883
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"We found that similar to USP14 shRNA, inhibition of USP14 by IU1 also significantly decreased AR protein level in breast cancer cells, supporting the conclusion that proteasomal DUB USP14 regulates the expression of AR in breast cancer cells."
29353883