IndraLab

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OTULIN inhibits Glu-Ala. 3 / 3
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"Consistent with our hypothesis, OTULIN silencing reversed the inhibitory effect of EA on the secretion of pro inflammatory factors in the ischaemic cerebral cortex."
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"EA also enhanced microglial OTULIN expression in the present study, and OTULIN silencing effectively reversed the inhibitory effect of EA on microglial activation, as shown by the increased mean Iba-1 immunofluorescence intensity, which strongly indicates that enhanced OTULIN expression is necessary for EA to alleviate microglial activation."
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"OTULIN silencing reversed EA suppression of microglial activation after focal cerebral ischaemia and reperfusion injury."
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