IndraLab

Statements

COPS6 activates CARD16. 3 / 3
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reach
"Mechanistic studies show that CSN6 binds and regulates FOXO4 stability through enhancing the E3 ligase activity of COP1, and that COP1 directly interacts with FOXO4 through a VP motif on FOXO4 and accelerates the ubiquitin-mediated degradation of FOXO4."
33101846
reach
"These data imply that CSN6 possibly regulates the gene expression of SGOC genes and impacts SGOC amino acid metabolism through its negative impact on FOXO4 that transcriptionally suppresses the gene expression of SGOC genes.2.6 PKB/Akt-Mediated CSN6 Phosphorylation Enhances COP1-Regulated FOXO4 Ubiquitination and Subsequent Elevation of SGOC Genes."
33101846
reach
"The mRNA levels of COP1 were not affected by CSN6 expression in a real-time quantitative PCR analysis (XREF_SUPPLEMENTARY), suggesting that CSN6 up-regulates COP1 at the post-transcriptional level."
21625211