IndraLab

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UCHL1 increases the amount of UCHL1. 13 / 14
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"Moreover, SMMC-7721 cells were transfected with UCHL1 overexpression vector; XREF_FIG shows transfection of UCHL1 overexpression vector effectively elevated the expression of UCHL1 in SMMC-7721 cells."
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"PcDNA3.1-UCH-L1 plasmid and UCH-L1 siRNA caused specific and effective up- or down-regulation of UCH-L1 expression, respectively."
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"AS Uchl1 induces UchL1 expression by increasing its translation."
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"The Uchl1 overexpression, induced by intracranial injection of Uchl1 expressing virus, decreases the Abeta production and protects AD model mice against memory impairment."
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"AS Uchl1 shuttles from the nucleus to the cytoplasm upon rapamycin induced mTOR activity in a dopaminergic cellular model, where it targets Uchl1 mRNA to active polysomes to facilitate its translation and upregulate Uchl1 protein levels (Carrieri et al., 2012)."
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"For example, antisense Uchl1 increases UCHL1 protein levels via an embedded inverted SINEB2 element."
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"AS Uchl1 caused an ~ 1.9-fold increase in UchL1 protein levels while maintaining stable Uchl1 mRNA levels, as expected for a post-transcriptional regulatory mechanism."
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"25,26 The results of our current study also suggest that the expression of PGP9.5 in lung cancer may play a causative role in the oncogenic transformation of human lung epithelial cells, because 1) PG[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our prior work revealed that UCH-L1 depletion led to cell death in three independent myeloma cell lines (KMS-11, KMS-18, KMS-28) expressing high levels of UCH-L1, whereas there was no impact on the growth of KMS-12 cells that express low levels [XREF_BIBR]."
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"The authors found that removal of a structural motif containing a short hairpin abolishes the ability of AS Uchl1 to upregulate UCHL1 protein levels, highlighting the importance of specific structural determinants of the SINE B2 sequence in the functionality of AS Uchl1 (Podbevšek et al., 2018)."
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"AS Uchl1 promoted the expression of Uchl1 protein by regulating Uchl1 mRNA, while down-regulated AS Uchl1 expression induced PD disease progression."
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"Given that Gene 33 deletion dramatically up-regulates UCHL1, Cr (VI) tends to promote UCHL1 expression, and that elevated UCHL1 is known to up-regulated in lung cancer, we propose that UCHL1 plays an important role in the early stage of lung epithelial cell transformation and lung tumorigenesis."
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"In a study on UCH-L1 and alphaII-spectrin levels in experimental rat models of IS and non traumatic hemorrhagic stroke, Ren et al. [13] detected significantly increased serum and CSF levels of UCH-L1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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