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UCHL1 increases the amount of UCHL1. 21 / 22
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"Moreover, SMMC-7721 cells were transfected with UCHL1 overexpression vector; XREF_FIG shows transfection of UCHL1 overexpression vector effectively elevated the expression of UCHL1 in SMMC-7721 cells."
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"Finally, to test whether UCHL1 upregulation results from increased transcription, qPCR was performed and confirmed no differences in UCHL1 mRNA levels in renal and glomerular lysates of K256E- ACTN4 p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In a study on UCH-L1 and alphaII-spectrin levels in experimental rat models of IS and non traumatic hemorrhagic stroke, Ren et al. [13] detected significantly increased serum and CSF levels of UCH-L1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A possible explanation for this finding is that UCHL1 in testicular fibroblasts was secreted into the exosomes instead of being enriched in the virus-infected cells, suggesting that UCHL1-loaded exoso[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pre-clinical studies have suggested that physical exertion may upregulate genetic expression of UCH-L1 e.g., increased striatal and hippocampal mRNA expression of UCH-L1 in rats undergoing aerobic exercise (Liu et al. 2018, 2019; Kirchner et al. 2008)."
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"AS Uchl1 induces UchL1 expression by increasing its translation."
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"Results showed that the decreased levels of UCHL1 and proteasome 20S in NSCs cultured with reactive ACM were all rescued by overexpression of UCHL1 or C3aR blockade (Fig. 5J–L)."
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"Lentiviral UCHL1 or GPX1-siRNA was used to modulate UCHL1 or GPX1 expression, respectively."
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"Our prior work revealed that UCH-L1 depletion led to cell death in three independent myeloma cell lines (KMS-11, KMS-18, KMS-28) expressing high levels of UCH-L1, whereas there was no impact on the growth of KMS-12 cells that express low levels [XREF_BIBR]."
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"25,26 The results of our current study also suggest that the expression of PGP9.5 in lung cancer may play a causative role in the oncogenic transformation of human lung epithelial cells, because 1) PG[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The Uchl1 overexpression, induced by intracranial injection of Uchl1 expressing virus, decreases the Abeta production and protects AD model mice against memory impairment."
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"AS Uchl1 promoted the expression of Uchl1 protein by regulating Uchl1 mRNA, while down-regulated AS Uchl1 expression induced PD disease progression."
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"AS Uchl1 caused an ~ 1.9-fold increase in UchL1 protein levels while maintaining stable Uchl1 mRNA levels, as expected for a post-transcriptional regulatory mechanism."
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"AS Uchl1 shuttles from the nucleus to the cytoplasm upon rapamycin induced mTOR activity in a dopaminergic cellular model, where it targets Uchl1 mRNA to active polysomes to facilitate its translation and upregulate Uchl1 protein levels (Carrieri et al., 2012)."
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"The authors found that removal of a structural motif containing a short hairpin abolishes the ability of AS Uchl1 to upregulate UCHL1 protein levels, highlighting the importance of specific structural determinants of the SINE B2 sequence in the functionality of AS Uchl1 (Podbevšek et al., 2018)."
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"The nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 (Uchl1) increases the expression of UCHL1 protein, an enzyme involved in brain function and neurodegenerative dis[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Given that Gene 33 deletion dramatically up-regulates UCHL1, Cr (VI) tends to promote UCHL1 expression, and that elevated UCHL1 is known to up-regulated in lung cancer, we propose that UCHL1 plays an important role in the early stage of lung epithelial cell transformation and lung tumorigenesis."
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"For example, antisense Uchl1 increases UCHL1 protein levels via an embedded inverted SINEB2 element."
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"In addition, LDN57444 is a reversible active UCH-L1 site-specific inhibitor that improves leiomyoma cell migration, gel contraction, and collagen synthesis, and reverses UCH-L1 overexpression of cardiac hyperplasia [171,172]."
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"PcDNA3.1-UCH-L1 plasmid and UCH-L1 siRNA caused specific and effective up- or down-regulation of UCH-L1 expression, respectively."
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"We infected CFs with adenovirus encoding UCHL1, followed by treatment with PDTC at different concentrations for 2 h and stimulated cells with Ang II for 24 h. UCHL1 overexpression significantly upregu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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