IndraLab

Statements

Mutated PTEN decreases the amount of PTEN. 4 / 4
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"The involvement of PTEN in human mammary oncogenesis has been implicated from studies showing that germline PTEN mutation in Cowden disease predisposes to breast cancer, the frequent loss of heterozygosity at the PTEN locus, and reduced PTEN protein levels in sporadic breast cancers."
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"In the PCa epithelia, PTEN mutation and loss of heterozygosity significantly reduce PTEN protein levels and thereby negate the tumor suppressive properties of nuclear PTEN."
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"However, at a later time point in fracture healing when mature osteoblasts that produce osteocalcin were present, the Pten mutants had decreased Pten expression, and increased ossification, as shown by the increased thickness of bone at the proximal and distal ends of the callus."
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"Interestingly, we found that mutation of the PTEN Tyr 155 residue significantly increased the association of WWP2 with PTEN, followed by enhanced polyubiquitylation and reduced PTEN protein levels (XREF_FIG), indicating that some yet-to-be-identified tyrosine kinases may be involved in the regulation of the WWP2-PTEN interaction."
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