IndraLab

Statements

MiR-181b-1 activates CYLD. 6 / 6
| 6
reach
"STAT-3 directly activates miR-21 and miR-181b-1, which inhibit PTEN and CYLD tumor suppressors, leading to increased NF-kappaB activity required to maintain the transformed state."
21786215
reach
"STAT-3 directly activates miR-21 and miR-181b-1, which inhibit PTEN and CYLD tumor suppressors, leading to increased NF-jB activity required to maintain the transformed state."
21786215
reach
"CYLD is directly targeted by miR-181b-1 and miR-19, which leads to inflammation and tumor progression [XREF_BIBR, XREF_BIBR]."
33435638
reach
"STAT-3 directly activates miR-21 and miR-181b-1, which inhibit PTEN and CYLD tumor suppressors, leading to increased NF-κB activity required to maintain the transformed state."
21786215
reach
"MiR-21 and miR-181b-1 respectively inhibit PTEN and CYLD tumor suppressors, leading to increased NF-kappaB activity required to maintain the transformed state."
20797623
reach
"Taken together, these observations are consistent with a pathway in which miR-181b-1 directly targets CYLD, leading to increased NF-kappaB activity and maintenance of the inflammatory feedback loop necessary for the transformed states."
20797623